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Product Review
St. John's Wort Supplements Review
Find the Best St. John's Wort Supplement. Only 40% of St. John's Wort Supplements Pass Tests & Strength Varies Widely.
CL Answer
Are there any supplements I should avoid when taking an antibiotic? Are there any that may be helpful?
Find out which supplements can negatively interact with antibiotics, including vitamin K, magnesium, and calcium, and which may be helpful when taking antibiotics.
CL Answer
What are the best supplements for depression and anxiety?
Best natural supplements for depression and anxiety, including the evidence for fish oil, vitamin D, probiotics, and herbal supplements for depression such as curcumin (from turmeric) and saffron.
CL Answer
Supplements for Attention-Deficit/Hyperactivity Disorder (ADHD): Are Any Helpful?
Dietary supplements are often explored as alternative options or add-on interventions for people with ADHD. Learn which, if any, have shown possible benefit and which don’t seem to help or may interfere with ADHD medication.
CL Answer
Is it safe to take arginine, or other supplements for sexual enhancement, while taking Viagra or Cialis?
When taking Cialis or Viagra, is it safe to take arginine or other sexual enhancement supplements?
CL Answer
I take fluoxetine (Prozac), a SSRI drug to treat depression. Are there supplements I should avoid, or be taking, due to this drug?
Learn about Prozac (fluoxetine) drug interactions along with other supplements and SSRIs.
Clinical Update
10/10/2014
Caution with St. John's Wort
St. John's wort is known to interact with a large number of prescription drugs. That number grew larger recently when the FDA approved two new drugs to cure hepatitis C infection. Taking these drugs while using St. John's wort may lead to reduced therapeutic effect and is not recommended. More information about this and other drug interactions with St. John's wort is found in the "Concerns and Cautions" section of the St. John's Wort Supplements Review >>
Product Update
11/03/2025
St. John's Wort – 22 Products Fail
Twenty-two out of 23 St. John's wort supplements sold on Amazon fell short on a key St. John's wort compound -- 6 had none at all! See details in our St. John’s Wort Supplements Review, which includes our Top Pick for St. John's wort.
CL Answer
What supplements should I stop taking before surgery?
Info on which supplements to avoid before surgery due to increased risk of bleeding or interference with anesthesia.
CL Answer
I've heard that grapefruit juice can interact with medications because it inhibits an enzyme that breaks down drugs in the body. Do any supplements interact the same way with drugs?
CYP3A4 inhibitors, such as grapefruit, can interact with certain medications by inhibiting the liver enzyme that metabolizes many drugs. ConsumerLab.com's answer explains.
CL Answer
Are there supplements, foods, or beverages that I should avoid when taking clopidogrel (Plavix)?
Learn about supplement interactions with clopidogrel (Plavix). Supplements that may interact with this medication include cannabidiol (CBD), grapefruit, St. John's wort, ginkgo and others.
Clinical Update
8/05/2015
Adverse Reactions with St. John's Wort
A recent analysis found adverse reactions associated with St. John's wort were similar to those reported for the prescription SSRI antidepressant fluoxetine (Prozac), and serious adverse reactions were most likely to occur when the herb was taken in addition to a prescription drug. Get the details, plus more about concerns and potential drug interactions and our tests of popular supplements in the St. John's wort Supplements Review >>
CL Answer
I take warfarin (Coumadin), an anticoagulant drug. Are there supplements I should avoid, or be taking, due to this drug?
Find out which supplements should be avoided when taking blood thinners (anticoagulants) like warfarin (Coumadin), including vitamin K, St. John's wort, and curcumin.
CL Answer
I take lisinopril (Zestril), an ACE inhibitor drug to lower blood pressure. Are there supplements I should avoid, or be taking, due to this drug?
When taking ACE inhibitors, find out which supplements should be avoided. Interaction info on Lisinopril or another ACE inhibitors.
CL Answer
Which supplements can cause diarrhea?
Can supplements like magnesium cause diarrhea? Find out which supplements may cause diarrhea, such as vitamin B12, curcumin, magnesium, vitamin C and fish oil.
Clinical Update
6/21/2024
Unlisted Plants in Herbal Supplements?
A DNA analysis of herbal supplements in 2013 suggested that many contained plants not listed on labels. However, some of those findings seem to have been made-up, according to a recent investigation. For details, see the update in the St. John’s Supplements Review.
Clinical Update
7/08/2024
Herbal Supplement Study Retracted
A DNA study that suggested widespread problems with herbal supplements has been retracted. Get the details in our St. John’s Wort Supplements Review.
Clinical Update
10/13/2013
Most Herbal Products Don't Contain Listed Herb
DNA analysis of 44 herbal products from Canada and the U.S. found that only 48% contained the herb listed on the label and one-third of these products contained contaminants or fillers not listed on the label (Newmaster, BMC Med 2013). Nine percent of products contained only rice or wheat and none of the listed herb. Many cases of herb substitution were reported, including senna (a laxative) in a product labeled as St. John's wort. Several products were contaminated with feverfew, which should not be consumed by pregnant women and may react with a variety of medications. The researchers, from the University of Guelph in Ontario, did not disclose the identities of the tested products, which were single-ingredient herbs sold as capsules, powders, or tablets. Significant challenges continue to exist for routine use of DNA analysis of herbs, but ConsumerLab.com may use this technique where appropriate in the future, alongside other analytical techniques in its Product Reviews.
News Release
September 26, 2016
60% of St. John's Wort Supplements Fail ConsumerLab.com Tests of Quality
White Plains, New York, September 26, 2016 — St. John's wort extracts can be as effective as standard antidepressant drugs for treating mild to moderate major depression, with significantly fewer side effects. However, recent ConsumerLab.com tests revealed that six of ten St.
News Release
April 14, 2010
ConsumerLab.com reports most St. John's wort supplements fail quality tests -- An effective antidepressant herb but heavy metal contamination and low potency are concerns
White Plains, New York — April 14, 2010 — St. John's wort has been shown to be effective in treating mild to moderate forms of major depression, but a new report from ConsumerLab.com shows that few of the herbal supplement brands recently tested met quality standards. Among the ten St.
News Release
February 14, 2007
ConsumerLab.com reports on anti-depressant herb — St. John's Wort — Few supplements pass quality testing
WHITE PLAINS, NEW YORK — FEBRUARY 14, 2007 — St. John's wort may be helpful in treating mild to moderate cases of clinical depression, but a new report from ConsumerLab.com shows that few of the herbal products tested met quality standards. Americans purchased $64 million of St.
News Release
April 27, 2004
New ConsumerLab.com report on St. John's wort highlights benefits and risks of herbal product for depression
NEW CONSUMERLAB.COM REPORT ON ST.
News Release
July 10, 2002
Pharmavite dietary supplements receive ConsumerLab.com approval — Vitamin E, SAM-e, St. John's Wort, Ginkgo and others merit approved quality products ranking
WHITE PLAINS, NY — July 10, 2002 — ConsumerLab.
News Release
April 10, 2001
Quality of popular herbal anti-depressant found to vary; certain types of St. John's Wort supplements more likely to pass testing
White Plains, NY — April 11, 2001 — ConsumerLab.com, an independent evaluator of dietary supplements and nutrition products, today released results of its Product Review of St. John's wort supplements.
Recalls & Warnings
June 12, 2025
NOW Nutritional Yeast Powder Recalled
On May 8, 2025, Now Foods recalled 18,658 units of NOW Nutritional Yeast Powder because regular yeast was inadvertently packaged as nutritional yeast.
Recalls & Warnings
February 22, 2021
FDA Warns Sellers of St. John's Wort
On February 18, 2021, the FDA issued warning letters to two companies following reviews of the companies' websites, which found statements made about the companies' St. John's Wort products to be drug claims. These products include St.
Recalls & Warnings
February 09, 2016
St. John's Wort Supplements Recalled
On February 8, 2016, the Medicines and Healthcare products Regulatory Agency (MHRA) (the British equivalent of the FDA) announced that certain St. John's wort supplements are being recalled because they contain excessive levels of a toxic pyrrolizidine alkaloid (PA).
Recalls & Warnings
May 03, 2013
Maker of Omega-3, Saw Palmetto, St. John’s Wort Supplements And More Warned For Manufacturing Violations and Drug Claims
On March 19, 2013, the FDA issued a warning letter to Sunset Natural Products Inc.
Recalls & Warnings
December 16, 2015
Maker of Red Yeast Rice, St. John's Wort, Valerian and More Warned for Manufacturing Violations, Drug Claims
On December 2, 2015, the FDA issued a warning letter to Nature's Health, LLC, following a facility inspection which found the company's product, including Ginkgo & Rhodiola, Blood Sugar Balance IV, Cinnamon Extract, Choles-Balance Red Yeast Extract, Lecithin, Milk Thistle Seed Extract, ...
Recalls & Warnings
April 17, 2015
Herbal Laxative and "Detox" Kit Containing High Levels of Lead and/or Arsenic Recalled in Canada
On April 15, 2015, Health Canada (the Canadian equivalent of the U.S. FDA) announced that St. Francis Herb Farm Inc.
Recalls & Warnings
July 13, 2012
Alistrol Health Inc. Warned Over Health Claims on Products
On June 26, 2012, the FDA issued a warning letter to Alistrol Health Inc. for making product statements on the company's websites that constitute drug claims.
Recalls & Warnings
September 16, 2015
Herbal Extracts Recalled
On September 15, 2015, Iowa Select Herbs, LLC issued a recall of numerous herbal exacts following a permanent injunction which required the company to stop selling supplements.
Recalls & Warnings
November 03, 2014
Mixing Medications and Dietary Supplements Can Be Dangerous, FDA Warns
On October 27, 2014, the FDA advised consumers to be aware of potential interactions between dietary supplements and over-the-counter (OTC) medications and/or prescription medications.
Recalls & Warnings
November 28, 2014
Seller of Herbal Extracts Warned for Manufacturing Violations, Drug Claims
On November 3, 2014, the FDA issued a warning letter to Avena Botanicals, Inc.
Recalls & Warnings
August 30, 2012
Supplement Company Warned For Medical Claims and Misbranding Of Omega-3, CoQ10, Noni Juice And More
On July 12, 2012, the FDA issued a warning letter to Alfa Vitamins Laboratories, Inc.
Recalls & Warnings
November 07, 2015
Seller of "NaturalDoctor" Vitamin C, Echinacea and More Warned for Manufacturing Violations
On October 16, 2015, the FDA issued a warning letter Sound Healing Arts, PC, dba Grounds for Tea, LLC, following a facility inspection which found the company's products, including NaturalDoctor Vitamins C & K3, NaturalDoctor Goldenseal & Echinacea Plus, NaturalDoctor Centella ...
Recalls & Warnings
October 21, 2014
Seller of Weight Loss, Saw Palmetto Supplements and More Warned for Drug Claims
On October 9, 2014, the FDA issued a warning letter to Bethel Nutritional Consulting, Inc., following a review of the company's website which found statements made about 15 Day Detox Diet, Alpha Lipoic Acid. 300 mg.
Recalls & Warnings
August 26, 2014
Maker of Herbal Supplements Warned for Manufacturing Violations and Drug Claims
On August 8, 2014, the FDA issued a warning letter to EnerHealth Botanicals, LLC following a facility inspection which found the company's products, including Parasite Purge Herbal Remedy, Black Walnut Extract, Bladder Cleanse Herbal Extract, Lung Renewal Herbal Remedy, EchinOsha and Daily Immune ...
Recalls & Warnings
May 30, 2014
Seller of Brain, Diabetes, Echinacea Supplements and More Warned for Drug Claims
On April 22, 2014, the FDA issued a warning letter to Mundo Natural Inc., following a review of the company's website which found statements made about supplements Neuro AD, Stop Diabetes, Stop High Blood Pressure, Morninga 7 and Purpurea Echinacea to be drug claims.
Recalls & Warnings
January 17, 2017
Seller of Heart, Senior and Teen Supplements Warned For Drug Claims
On December 7, 2016, the FDA issued a warning letter to Esteem Products Ltd following a review of the company's website, which found statements made about its products, Cardio Life, Total Man, Total Woman, Senior Total Man, Senior Total Woman , and Total Teen to be drug ...
Recalls & Warnings
February 19, 2014
Seller of Sexual Enhancement Supplements Warned For Manufacturing Violations
On February 11, 2014, the FDA issued a warning letter to Maximus Niterider International Group, Inc.
Recalls & Warnings
December 16, 2013
Weight Loss Capsules Recalled Due Allergen Risk
On December 13, 2013, Stone Independent Research, Inc. issued recall of one lot of Zanocap Scientific Weight Loss 500 mg capsules because they contain undeclared whey protein, which is derived from milk.
Recalls & Warnings
January 30, 2013
Seller of Omega-3 and Emu Oil Supplements Warned For Drug Claims, Misbranding
On November 19, 2012, the FDA issued a warning letter to Emu Products & Management, Inc. after a review of the company's website found statements that promoted the dietary supplements Multi-Omega Gel Caps, Recovery Gel Caps, ARP Gel Caps and the topical skin products Extreme Cryo Gel, F.A.C.E.
Recalls & Warnings
December 26, 2012
Seller of Blood Sugar, Depression and Sleep Supplements Warned For Making Drug Claims
On October 15, 2012, the FDA issued a warning letter to BioNeurix Corporation after statements found on the company's website, http://www.pharma-tree.com, were found to promote the dietary supplements Blood Sugar 360, Amoryn, Seredyn, and Mellodyn as drugs.
Recalls & Warnings
February 03, 2015
Major Retailers Accused of Selling Adulterated Herbal Supplements
On February 3, 2015, the New York State Attorney General announced that his office sent letters to four major retailers, GNC, Target, Walmart, and Walgreens, for allegedly selling store brand herbal supplement products in New York that either could not be verified to contain the labeled substance, ...
Recalls & Warnings
June 20, 2003
Mixing Herbal Supplements, Migraine Medications Can Be Dangerous
On June 19, 2003, ABC News reported than an extensive review of existing research has led University of Utah researchers to conclude several popular herbal supplements may cause adverse, even deadly, reactions when combined with certain migraine medications.
Recalls & Warnings
May 14, 2014
Maker of Mood, Smoking Cessation Supplements and More Warned for Violations, Drug Claims
On April 17, 2014, the FDA issued a warning letter to CDJ Holding, Incorporated, d.b.a.
Recalls & Warnings
August 06, 2016
Some Supplements May Cause or Exacerbate Heart Failure (Includes vitamin E and many herbs)
Taking certain supplements may be dangerous for people with heart failure, according to a statement from the American Heart Association (AHA) which was published in the journal Circulation (August 2, 2016).
Recalls & Warnings
September 07, 2002
FDA Sends Warning Letters to Seven Online Supplement Sellers For Therapeutic Claims
On August 27, 2002, the FDA posted seven "Cyber" letters recently issued from its Center for Food Safety and Applied Nutrition (CFSAN) to internet website operators promoting dietary supplement products that claim to diagnose, mitigate, treat, cure, or prevent a specific disease or class of ...
Recalls & Warnings
March 21, 2013
Probiotic Recalled Due To Undeclared Soy
On March 20, 2013, New Chapter, Inc. issued a voluntary recall of one lot of its Probiotic Elderberry dietary supplement because it may contain undeclared soy.
