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Product Review: Resveratrol Supplements (Grape, Red Wine, and Polygonum Sources)
 



How Products were Selected:
Products tested represent those commonly sold and/or available nationally in the U.S. and Canada. ConsumerLab.com purchased products on the open market through retail stores, on-line retailers, and direct sales or multi-level marketing companies. Products were not accepted directly from manufacturers.

Testing Method:
Resveratrol products were tested for their total trans and cis resveratrol content. All products were first analyzed in a independent laboratory using a HPLC (High Performance Liquid Chromatography) assay. Products not passing this initial assay were tested in a second independent laboratory utilizing a similar HPLC assay.

Analyses for lead and cadmium were performed using an ICP-MS (inductively Coupled Plasma-Mass Spectroscopy).

Disintegration of non-chewable, non-capsule, non-enteric coated and non-time-release formulations was analyzed utilizing USP (United States Pharmacopeia) <2040> recommendations.
 
Any product not passing testing was sent to another independent laboratory to repeat testing the criteria on which it did not pass.
 
Identities of products were not disclosed to laboratories performing the testing.

Passing Score:*
To pass, a product must:
  1. Contain 100% of resveratrol label claims for the total amount resveratrol and specific resveratrol forms. Total Resveratrol = sum of (total free trans/cis resveratrol) + (total trans/cis polydatin x 0.587) (note: polydatin glycoside is composed of 58.7% resveratrol).
  2. Meet recommended USP parameters for disintegration for dietary supplements (excluding capsule, enteric coated, chewable and time-release products).
  3. Meet the State of California's Prop 65 limits for lead in supplements: 0.5 mcg of lead per daily serving with an additional allowance of 1.0 mcg for supplements containing 1,000 mg/day or more of elemental calcium and 0.5 mcg for supplements containing specific other minerals. For supplements not marketed for use by children, ConsumerLab.com provides an additional allowance of 0.5 mcg if containing 250 to 499 mg/day of elemental calcium or 1.0 mcg if containing 500 to 999 mg/day of elemental calcium and an allowance of 0.5 mcg for if containing one whole herb (not extract) ingredient or 1.0 mcg for two or more whole herb ingredients. If a maximum recommended daily serving is not defined, a daily serving size will be determined and applied by CL. 
  4. Contain less than 0.3 parts per million (or micrograms per gram) of cadmium for dried raw herb (World Health Organization, Quality Control Methods for Medicinal Plant Material, proposed guidelines, 1998) or less than 0.1 parts per million for extracts. The lower concentration standard for extracts reflects the ability to remove heavy metals such as cadmium during the extraction process.
A "Pass" was based on meeting the above criteria in either the first or second rounds of testing.

* Passing scores allow for specific margins of technical error associated with each analysis. ConsumerLab.com reserves the right to disqualify a product at any time from passing its testing if it considers such product to present a safety risk or to provide misleading or inaccurate information in its labeling.


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