Gift Membership  
Join FREE Newsletter

My Account Logout Contact Us Subscribe Now! Login Contact Us
Home Product Tests  Warnings  Encyclopedia News Where to Buy Answers  

I am curious why some probiotics do not require refrigeration even though they contain some of the same bacteria in probiotics that require refrigeration? Which probiotics need to be refrigerated?

Proper refrigeration is critical for many probiotics, both before and after they are purchased. In fact, in 2009 the majority (85%) of probiotics selected for testing by did not contain their listed amounts of organisms and, as later learned, improper shipping and warehousing by distributors and retailers appears to have been at least partly to blame. Fortunately, found better results in early 2012 (17% of products failed testing), probably due to improvements in refrigeration procedures by several companies.


Many probiotic bacteria are sensitive to heat and moisture. Heat can kill organisms and moisture can activate them within pills, only to die due to lack of nutrients and a proper environment. These products should ideally be refrigerated.

Probiotics with freeze-dried organisms in appropriate packaging to prevent moisture, such as blister packs, generally do not need refrigeration. They also have longer shelf-lives than products containing live organisms, such as liquid products (which must be refrigerated). Probiotic yeast and some of the spore-forming bacteria, such as Bacillus coagulans, generally do not require refrigeration.

If you are purchasing a probiotic with a label that suggests or requires it be refrigerated, be sure your retailer has kept it refrigerated. If you order the product by mail, such as from an online retailer, be sure it is shipped overnight or with refrigerated shipping to minimize exposure to extreme heat.

Once you get the product, be sure to follow the manufacturer's recommendations. If in doubt, refrigerate.

For more information about probiotics and's latest tests and comparisons, see the Product Review of Probiotic Supplements.

See other recent and popular questions >>
Popular Reviews
Multivitamin and Multimineral Supplements
Make Sure Your Multivitamin Passed! Check Results for 60 Products
Multivitamin and Multimineral Supplements
Multivitamins Put to the Test; Defects Found in Nearly 40%
Fish Oil /Omega-3 Fatty Acid Supplements
Fish Oil, Krill Oil, Algal Oil and Calamari Oil Supplements Reviewed Encyclopedia

In addition to our product reviews our encyclopedia covers the following:


Follow on Twitter    |     Become a Fan on Facebook
Join | Sign In
Home | Product Tests | Brands Tested | Encyclopedia | CL Answers | Clinical Updates | Where to Buy Products | Group Subscription
News | Recalls & Warnings | Raw Materials Tests | Testing Programs | The CL Seal | CL Survey | About Us
In The News | RDAs | Gift Memberships | Join Free Newsletter | Privacy Policy | Site Map | Testimonials | Contact Us/Help

©2014, LLC. All rights reserved. A single copy of a report may be printed for personal use by the subscriber.
It is otherwise unlawful to print, download, store or distribute content from this site without permission. name and flask logo are both registered trademarks of, LLC.