Initial Posting: 3/15/2016    Last Update: 1/16/2020
Question: Are CoQ10 and ubiquinol safe to take for a long period of time? Should I give it a rest period?
Answer: Studies with CoQ10 have not shown serious adverse effects at moderate doses even when taken for several years — although it may be best to divide the dose over the course of the day. (For more information about CoQ10 dosages used for reducing statin-related muscle pain, congestive heart failure, migraines and other uses, see the Dosage section of the Review).