Aspirin, ibuprofen (Advil, Motrin), and other nonsteroidal anti-inflammatory drugs (NSAIDS), like naproxen (Aleve), celecoxib (Celebrex) and diclofenac (Arthrotec, Voltaren) can be affected by taking supplements and can affect your ability to absorb certain vitamins and minerals. Some supplements, for example, can increase the risk of bleeding or stomach irritation associated with the use of these drugs. On the other hand, certain supplements may be beneficial for people taking NSAIDS.  

These interactions are explained in the Nonsteroidal Anti-inflammatory Drugs article, which is part of the extensive Drug Interactions section of our website (where you can look up interaction for other drugs you may be taking).

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May 4, 2016

I take turmeric spice, a few shakes at a time from my Simply Organic bottle, in water as a mild painkiller. I've done this many times over a two-year period. It was an effect I discovered on my own, based on taking it for basic health reasons. It has not affected my stomach. The effect is short in duration, perhaps two hours. I often take it simply because I don't feel up to par, or, when I have pain from an infrequent sinus infection. I rarely use other painkillers. If you have any clinical support for this effect of turmeric, I think it would be worth mentioning.

December 1, 2015

I don't take Turmeric supplements. Turmeric is a wonderful spice and I sprinkle a bit of it in most meals as I do salt and pepper. I am hoping that it makes up the equivalent of taking the supplement. Same thing I do with Cayenne pepper hoping to increase my metabolism with very subtle nudges off the spice rack. I also spice with Ginger, both fresh and powdered, and substitute olive oil and coconut oil for vegetable shortening and sometimes butter. I wonder how much value I get from "spicing" vs supplements?
December 2, 2015

Hi John - Thank you for your question. We've now answered it, here:

November 30, 2015

I take Krill, curcumin, garlic, eat ginger etc...and noticed no issues with bleeding. Although i never take pain pills i use natural methods and probably resort to Advil once or twice a year.

May 10, 2016

Krill is not the best source of omega-3. Other species like anchovies and sardines (marine oils) are much richer tan krill. Look at a common krill products label and compare the amount of omega-3 delivered. Brands like OAMX3 and Nordic deliver much more of this essential fatty acid

May 6, 2015

I've not seen this mentioned, with all the ado about Tumeric, but my husband and I decided to try it. We were taking the supplement (I'm sorry, I don't know the milligrams but it was not excessive, probably the recommended amount) for a few weeks and my husband started getting nosebleeds. For myself, I noticed a lot more bruising where there was no real reason or injury. I thought about it and realized the only thing that had changed was the addition of Tumeric. I didn't connect at first, the fact that we both take a high does of fish oil, which can act as a blood thinner. I then researched tumeric and found it could act in the same way, so the combination likely caused the nose bleeds (which he'd been prone to as a child) and the bruising, which I also am prone to. We stopped the tumeric and both issues went away. So if you take any other blood thinning substances, you could still try tumeric but be on the look out for the issue, especially if you have a surgery coming up.
May 6, 2015

Hi Harise - Thank you for letting us know about your experience with this. Curcumin does have anti-platelet activity and should be avoided when taking blood-thinning medication, and should be used with caution if you take other supplements which have a blood-thinning effect. See the Cautions section of the Turmeric and Curcumin Supplements and Spices Review:

May 6, 2015

I added cur cumin and also green lipped muscles at the same time and noticed about a week later that I had broken out with pimples on my lower jaw....last pimple I had was 1961.....high I suit both and decide to try one at a time to see which one it was....any input?
May 28, 2015

Hi Nonna - Some people have reported a worsening of acne when taking omega-3 supplements. However, a clinical study found EPA and DHA (the omega-3s found in fish oil and green-lipped mussel oil) reduced the severity of acne, and no worsening of acne was reported in any of the participants (see the "What to Consider When Using" section Fish Oil and Omega-3 Fatty Acid Supplements Review for more about this: There do not appear to be any studies reporting specifically on green-lipped mussel oil and acne.

Although we are not aware of any studies showing curcumin causes acne, it could potentially cause an allergic skin reaction in some people (see the "Cautions" section of the Turmeric and Curcumin Supplements Review:

What were your results when you tried taking one at a time?

January 18, 2017

I wonder if rancid fish oils could be a problem?

February 13, 2017

As just an opinion, but one that might be hard to refute, these comments posted here underscore the fact that everyone's body is different. For example, my spouse reacts 180 degrees opposite from what I do when taking magnesium pill supplements. Yet liquid mag does not cause her the upset that the capsules do. I closely monitor my own body for reactions to anything put into it, be it supplements, food, herbs, or medications (I don't take any prescription ones) and balance that with the general info about the specific substance (aspirin-bleeding, selenium-squamous skin cancer, sugar-heart disease, etc).

As for aspirin, I've read of a few studies that showed that, taken with vitamin C or taken with DGL licorice, there was much less bleeding and damage to the stomach and intestinal tract. So whenever I take aspirin, I also down a 1000 mg ascorbic acid cap and a 750 mg DGL cap and hope for the best. I have no empirical evidence one way or the other, but perhaps the info will help someone else who takes aspirin.Even if it helps me, it might not do the same for you, but sharing info can't hurt.

Doesn't seem like rocket science to me; if something causes bad or unpleasant things to happen in your body, stop taking it. Do some research. If you think you need what that substance offers, look for an alternative, a different brand, different formulation, or different potency.

October 2, 2016

I take Celebrex, lo dose aspirin, Nexium, turmuric (large dose), ginger, and fish oil. I have found unless I skip the aspirin and fish oil in the morning when I go for dental cleaning, my gums bleed excessively.

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