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Question:
Can taking N-acetylcysteine (NAC) supplements reduce my risk of liver damage from acetaminophen?

Answer:
Although N-acetylcysteine (NAC) is used medically to treat acetaminophen (Tylenol) overdose, no studies in people have evaluated the effects of taking NAC with acetaminophen to prevent acetaminophen-related liver damage. The only studies like this to-date have been in animals. For more details about this and other uses of NAC, see the "What It Does" section of the NAC Supplements Review >>

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Also see these related CL Answers:



Are there any supplements I should avoid when taking aspirin or ibuprofen? >>

Are there any supplements I should avoid when taking acetaminophen? >>



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Stephanie 13926   April 21, 2017
I have been taking NAC with acetaminophen my liver enzymes are perfect.

Jeanne12853   March 27, 2017
Acetaminophen depletes glutathione in the liver, NAC is a building block of glutathione, which is a major antioxidant of the body.
I always recommend patients take NAC if they take acetaminophen ,or a product containing it , with any regularity. One such example being pain medications like Tylenol, Fiorecet, hydrocodone etc.

This CL Answer initially posted on 3/24/2017. Last updated 7/25/2017.

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