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Melatonin Supplements Reviewed by ConsumerLab.com

Melatonin: Potential Drug Interactions

Question:
I take melatonin to help me fall asleep. Are there any drugs that interact with melatonin that I should be aware of?

Answer:
Melatonin supplements may increase the effects of certain drugs, and may decrease the effectiveness of others, including blood pressure medications. Also be aware that certain drugs (and even caffeine) may increase the amount of melatonin you absorb from supplements, potentially increasing its effects. For details, see the Caution and Concerns section of the Melatonin Supplements Review >>

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Also see these related CL Answers:



What is the best way to take melatonin to get a good night's sleep? >>

I've heard that taking vitamin D can reduce your natural production of melatonin and interfere with sleep. Is this true? >>

Is it safe to take melatonin when taking prescription sedatives or sleep aids like lorazepam (Ativan) or zolpidem (Ambien)? >>

I've heard that melatonin may increase the risk of broken bones. I take melatonin regularly. Should I be concerned? >>



See other recent and popular questions >>
Comments
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Kelsey16385   January 29, 2018
Does ashwaganda interact with melatonin? I've read Ashwaganda is not to be taken with sedatives like Ativan but am unsure if that applies to melatonin as well?

ConsumerLab.com   January 31, 2018
Hi Kelsey - We are not aware of any studies or reports on this specific combination, but please see the "Concerns and Cautions" section of the Ashwagandha Review which discusses taking with sedating herbs/medications: https://www.consumerlab.com/reviews/ashwagandha_supplements/ashwagandha/#cautions

Ellen13978   May 3, 2017
Do the cautions on melatonin supplements apply to melatonin from natural sources as well, such as Tart Cherry Juice?

ConsumerLab.com   May 3, 2017
Probably not, Ellen, as the amount of melatonin in tart cherry is very small. Roughly speaking, a serving would provide only one-tenth of a normal "low" dose of melatonin. See the CL Answer about tart cherry for more details at http://www.consumerlab.com/answers/What+are+the+benefits+of+tart+cherry+juice%3F/tart_cherry/

Sally13976   May 3, 2017
According to RxList: Warfarin oral increases effects of melatonin oral by the risk of side effects and cause bleeding or bruising. Melatonin reduces blood clotting.

ConsumerLab.com   May 3, 2017
Hi Sally - Information about melatonin's effect on blood clotting and use with blood-thinning medications is found in the "Cautions" section of the Melatonin Supplements Review: https://www.consumerlab.com/reviews/_/melatonin/#cautions

Laurie16374   January 28, 2018
This is interesting and probably explains why I get nose bleeds with regular use of Melatonin. I made the connection and stopped taking it regularly because over time I only had to up the Melatonin dosage to be effective. Not worth the side effect, though, so I stopped taking it altogether and look for a supplement that contains little or none and only take it periodically, if necessary.

This CL Answer initially posted on 5/2/2017. Last updated 7/25/2017.

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