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Question:
Do diamine oxidase (DAO) supplements for histamine intolerance really work?

Answer:
Histamine intolerance refers to a wide range of symptoms (such as itching, rash, headache, gastrointestinal distress and difficulty breathing) that can be triggered in some people by eating foods rich in histamine or by taking certain drugs. There is evidence that in some people, these symptoms could be caused by low activity of the DAO enzyme, which helps to break down histamine in the body. Supplements containing DAO are promoted to help break down histamine and reduce these symptoms. See full answer for more information including foods to avoid, studies with DAO supplements, and DAO dosage >>

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This CL Answer initially posted on 6/11/2014. Last updated 4/29/2018.

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