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Question:
Do magnesium supplements, like Magtein, help memory or protect against Alzheimer's disease?

Answer:
Magnesium plays an important role in brain cell function and some preliminary research in animals has suggested it may influence cognitive functions like memory and learning. A preliminary study in people found that magnesium-L-threonate (Magtein or Clarimem) may modestly improve certain measures of cognitive function. Overall, however, there is very limited evidence that taking magnesium improves memory or learning, or prevents Alzheimer's disease, in humans. For details, see the "What It Does" section of the Magnesium Supplements Review >>


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Suz16974   July 30, 2018
Just a personal experience. I have never been able to do oral Mg supplements as they trigger diarrhea. I tried many different ones, including Magbrite or some such that promised money back if side effects. I was using the external Mg solution but hated the sticky, burning feel of it. I have been doing the Mg threonate for about 3 years with no diarrhea and an unexpected but noticeable improvement in lethologia--having difficulty with recalling words and with short-term memory. As a teacher (age 77), I have been pleasantly surprised by this effect, which was not the reason I began using this type of Mg.

susan13889   April 2, 2017
following up on my previous comment. results of the study should be available in 2018. in the mean time my mother, who has alzheimer's, is taking the study dose daily.

susan11422   November 27, 2016
magtein a brand of magnesium l-threonate is currently being studied for use in mild/moderate dementia. https://www.nia.nih.gov/alzheimers/clinical-trials/magnesium-l-threonate-enhance-learning-and-memory-people-dementia

MAX 8032   November 4, 2015
Magnesium Oil topically applied to the body will stop restless legs. This is my personal experience.

Paul3756   June 7, 2015
Wei's retracted article concluded that " Our results suggest that elevation of brain magnesium exerts substantial synaptoprotective effects in a mouse model of AD and may have therapeutic potential for treating AD in humans."

However the retraction stated that " we discovered errors in the quantification of the expression and/or phosphorylation of a subset of signaling pathways, particularly related to Figures 4 and 5D. Despite these errors, the major conclusions of the paper remain substantiated. "

So it appears there are two rat model studies supporting this supplement...

It's unfortunate that the human study is overdue...

This CL Answer initially posted on 6/25/2014. Last updated 8/8/2017.

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