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How should curcumin dose be adjusted if using formulations with enhanced bioavailability such as Meriva, BCM-95, CurcuWin, Theracurmin, Bioperine, and C3?

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Hal14046   May 20, 2017
A recent article in forbes magazine references a study indicting there is no evidence in over 120 studies that Turmeric has any health benefits (https://www.forbes.com/sites/samlemonick/2017/01/19/everybody-needs-to-quit-it-with-this-turmeric-molecule/#79ff35fe79ff )
The study is at http://pubs.acs.org/doi/abs/10.1021/acs.jmedchem.6b00975 and concludes:
Curcumin is a constituent (up to ~5%) of the traditional medicine known as turmeric. Interest in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led to their extensive investigation. Curcumin has recently been classified as both a PAINS (pan-assay interference compounds) and an IMPS (invalid metabolic panaceas) candidate. The likely false activity of curcumin in vitro and in vivo has resulted in >120 clinical trials of curcuminoids against several diseases. No double-blinded, placebo controlled clinical trial of curcumin has been successful. This manuscript reviews the essential medicinal chemistry of curcumin and provides evidence that curcumin is an unstable, reactive, nonbioavailable compound and, therefore, a highly improbable lead. On the basis of this in-depth evaluation, potential new directions for research on curcuminoids are discussed.
Thoughts on this, please.

ConsumerLab.com   May 20, 2017
Hi Hal - We wrote about this study (Nelson, J Med Chem) when it came out earlier this year. It make some valid points but avoids discussion of formulations which overcome some of these issues. See the "What It Does" section of the Turmeric/Curcumin Supplements Review (https://www.consumerlab.com/reviews/turmeric-curcumin-supplements-spice-review/turmeric/#nelson) .

This CL Answer initially posted on 10/9/2016. Last updated 7/26/2017.

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