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Question:
Is it safe to take melatonin when taking prescription sedatives or sleep aids like lorazepam (Ativan) or zolpidem (Ambien)?

Answer:
Melatonin may increase side effects of sedative or sleep medication, although significant adverse events have not been reported in short-term studies. See the Concerns and Cautions section of the Melatonin Supplements Review for more information.

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Comments
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Frances11150   August 12, 2016
If people are having trouble sleeping they need to do 2 things before they rely on medications or supplements.

1. Make sure their sleep hygiene is good. See this link for great tips on sleep hygiene: https://sleepfoundation.org/ask-the-expert/sleep-hygiene

2. Make sure that they do not have some problems with their breathing during sleep. Sleep Apnea is just one form. I recommend Dr. Steven Park's book, Sleep Interrupted. There is also lots of great information on his website drstevenpark.com. There are lots of great articles and also an excellent podcast. You can also get his podcast--free!--on iTunes.

I am a retired physician and Dr. Park's website is the best resource I've found.

Sandra14001   May 8, 2017
Delighted to see your comment and the two sensible prerequisites to any medicating, over-the-counter or prescription. That you identify a resource and list your experience is incalculably helpful in both points. Thank you

Kathleen11146   August 10, 2016
I just read of a study in the UK that linked sleep aids, including melatonin, with an increased risk of broken bones. I take melatonin regularly and am concerned about this possibility. Have there been any other studies indicating this connection?

ConsumerLab.com   August 16, 2016
Thank you for your question Kathleen. We've now answered it here: https://www.consumerlab.com/answers/_/melatonin-fracture/

Frank11142   August 10, 2016
What about glycine for sleep? I believe it is supposed to increase sleep duration.

ConsumerLab.com   September 28, 2016
Hi Frank - Thank you for your question. We've now answered it here: https://www.consumerlab.com/answers/_/glycine-for-sleep/

This CL Answer initially posted on 8/9/2016. Last updated 7/26/2017.

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