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Question:
What is Metafolin (5-methylfolate)? I see it in some supplements instead of folic acid. Is it better than folic acid?

Answer:
Supplements have typically provided folic acid as their source of folate -- an essential B vitamin. In 2001 and 2010, respectively, Metafolin and Quatrefolic were approved in the U.S. as sources of folate in supplements. These two ingredients have some advantages compared to folate from foods and folic acid, and they differ somewhat from each other. You can get details about these ingredients in the section on Folate in the B Vitamins Review >>

Products containing Metafolin and Quatrefolic have been tested and reviewed in ConsumerLab.com's Multivitamin Supplements Review >>

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This CL Answer initially posted on 4/18/2013. Last updated 8/8/2017.

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