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Berberine Supplements

Trying to find the best berberine or goldenseal supplements? ConsumerLab tested 10 different products. Many failed our tests of quality. Find out why, see our top picks for berberine and goldenseal, and learn if these are effective for weight management, type 2 diabetes, fatty liver, high cholesterol, H. pylori infection, and other conditions.

Berberine Supplements Review

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News Release

September 14, 2023

Best and Worst Berberine and Goldenseal Supplements, According to ConsumerLab Tests

White Plains, New York, September 14, 2023 —  Recent ConsumerLab tests revealed problems with nearly 45% of the berberine and goldenseal supplements selected for testing. Powders and capsules containing goldenseal (which naturally contains berberine) were particularly likely to have issues.

News Release

December 12, 2017

Berberine and Goldenseal: Avoid Fakes! -- ConsumerLab.com Testing Reveals the Best and Worst Supplements

White Plains, New York, December 12, 2017 — Berberine, a compound found in goldenseal root, may help to lower blood sugar in certain people, and may have other potential benefits. However, ConsumerLab.

CL Answer

Which supplements and foods can help lower or control blood sugar?

Find out which supplements can help lower or control blood sugar. Supplements including turmeric/curcumin, fiber, cinnamon, and ginseng are believed to help lower blood sugar.

Blood Sugar Control -- blood test and blood sugar chart

CL Answer

Is it dangerous to use certain herbals, vitamins, or other dietary supplements when breastfeeding?

Find out which supplements should be avoided when breastfeeding, including medicinal herbs, soy, and flaxseed.

Herbs and Supplements to Avoid When Breastfeeding

CL Answer

I've heard that grapefruit juice can interact with medications because it inhibits an enzyme that breaks down drugs in the body. Do any supplements interact the same way with drugs?

CYP3A4 inhibitors, such as grapefruit, can interact with certain medications by inhibiting the liver enzyme that metabolizes many drugs. ConsumerLab.com's answer explains.

Grapefruit Juice, CYP3A4 and Supplement Interactions -- glass of grapefruit juice and grapefruit halves

CL Answer

I take warfarin (Coumadin), an anticoagulant drug. Are there supplements I should avoid, or be taking, due to this drug?

Find out which supplements should be avoided when taking blood thinners (anticoagulants) like warfarin (Coumadin), including vitamin K, St. John's wort, and curcumin.

Warfarin Supplement Interactions -- bottle of pink warfarin tablets

Recalls & Warnings

December 11, 2020

Goldenseal Recalled Due to Microbial Contamination

On December 4, 2020, WishGarden Herbs, Inc. issued a recall of 14 lots of Cord Care Powder and Goldenseal Powder because they were manufactured using ingredients that were potentially contaminated with the bacterium Cronobacter sakazakii.

Clinical Update

6/05/2018

Berberine Side Effect

Supplements that contain berberine (a compound extracted from goldenseal) can cause a range of side effects, in addition to drug interactions. It was recently reported that berberine can cause a rare, but severe, skin reaction. Learn more in the Concerns and Cautions section of the Berberine and Goldenseal Supplements Review. Also see our Top Pick among products in this category.

Clinical Update

12/22/2023

Problems With Berberine Sold on Amazon

Recent tests of 33 berberine supplements purchased on Amazon and Walmart.com showed that many contained less than half the listed amount of berberine. Get the details, by brand, in our Berberine and Goldenseal Supplements Review, which includes our tests of popular brands and Top Picks for berberine and goldenseal.

Product Review

Echinacea Supplements Review

Many Echinacea Supplements Fail CL's Tests. Make Sure You Know What You're Getting!

Echinacea supplements reviewed by ConsumerLab.com

Clinical Update

7/31/2021

Improving Berberine Absorption?

Learn if special formulations have greater benefit than berberine alone, in the ConsumerTips section of our Berberine and Goldenseal Supplements Review.

CL Answer

What supplements should I stop taking before surgery?

Info on which supplements to avoid before surgery due to increased risk of bleeding or interference with anesthesia.

Supplements to stop before surgery - operating room

Clinical Update

2/04/2020

Berberine vs. Colon Cancer?

A large study investigated the potential for berberine (promoted for blood sugar control) to prevent precancerous colon polyps. Find out if it worked in the What It Does section of the Berberine & Goldenseal Supplements Review. Also see our Top Pick for berberine.

Clinical Update

11/22/2022

Berberine Top Pick Changed

We are no longer recommending our original Top Pick among berberine supplements. Find out why, and see our current product suggestion in the Top Picks section of our Berberine and Goldenseal Supplements Review.

Clinical Update

8/04/2023

Berberine for Prediabetes?

Does taking berberine help lower blood sugar and cholesterol in people with prediabetes? Find out what a recent study showed the Berberine section of our Berberine and Goldenseal Supplements Review.

Also see: Which supplements and foods can help lower or control blood sugar?

CL Answer

Are there supplements I should avoid when taking apixaban (Eliquis) or similar blood thinner drugs like Xarelto?

Learn about supplement interactions with apixaban (Eliquis), rivaroxaban (Xarelto) and other blood thinner drugs in the direct factor Xa inhibitors class.

Eliquis Supplement Interactions -- box of Eliquis

Recalls & Warnings

August 20, 2020

Goldenseal Recalled Due to Microbial Contamination, One Death Reported

On August 17, 2020, Maison Terre issued a recall of all lots of organic Goldenseal Root Powder because recent testing found it has the potential to be contaminated with various microorganisms including Enterobacter cloacae, Cronobacter sakazakii, Cronobacter dublinensis, and others.

CL Answer

8 Supplements That May Help Treat Peptic Ulcers – And Some to Avoid

Peptic ulcers caused by H. pylori infection are typically treated with antibiotics, but certain supplements may also help. Find out which 8 supplements might be beneficial - and which should be avoided.

Supplements for peptic ulcer disease - young man with stomachache

Product Review

Prostate Supplements Review (Saw Palmetto and Beta-Sitosterol)

Find the Best Prostate Supplement for Symptoms of BPH. See Which Prostate Supplement Passed or Failed CL's Tests of Quality.

CL Answer

Do any supplements help with fatty liver disease? Are some diets more beneficial than others?

Find out if supplements such as vitamin E, fish oil, milk thistle, curcumin, choline, probiotics, vitamin D, reishi mushroom, or extra virgin olive oil are beneficial for fatty liver disease and learn which diet (Mediterranean, ketogenic, DASH, or fasting diets) seems to have greatest benefit.

Overweight man holding his right side near his liver

CL Answer

Which supplements and lifestyle changes improve sleep, and which cause insomnia?

Find out which vitamins may help you sleep and learn if any vitamins or supplements can cause insomnia.

Recalls & Warnings

June 13, 2022

Homeopathic Nasal Spray SnoreStop Recalled Due to Microbial Contamination

On June 9, 2022, Green Pharmaceuticals Inc issued a voluntary nationwide recall of one lot of its SnoreStop NasoSpray, a homeopathic nasal spray promoted to reduce snoring, due to the presence of Providencia rettgeri, a bacterium that can cause severe illness in some people.

Recalls & Warnings

August 28, 2018

FDA Warns Seller of Goldenseal and Parasite Supplements

On August 15, 2018, the FDA issued a warning letter to Healthy Healing dba Crystal Star, following a facility inspection which found certain statements product labels, including product labels for Women's Best Friend and Para Purge, to be drug claims. 

Recalls & Warnings

April 17, 2018

FDA Warns Seller of Echinacea, Iron, Aloe Supplements & More for Manufacturing Violations

On March 30, 2018, the FDA issued a warning letter to Ozark Country Herbs following a facility inspection which found a number of the company's products, including Echinacea-Goldenseal, Natural Iron, and Aloe-Vera Goldenseal Salve, to be adulterated because they were prepared, packed, or held under ...

Recalls & Warnings

December 08, 2015

Non-Decolorized Aloe, Goldenseal Root Added to Prop 65 List of Cancer-Causing Chemicals

On December 4, 2015, California's Office of Environmental Health Hazard Assessment (OEHHA) added non-decolorized whole leaf extract of aloe vera and goldenseal root powder to the state's list of chemicals known to cause cancer - part of the Safe Drinking Water and Toxic Enforcement ...

Recalls & Warnings

January 13, 2022

Senna Laxative Recalled Due to Microbial Contamination

On January 11, 2022, Lohxa LLC issued a voluntary recall of one lot of Senna Syrup 8.

Recalls & Warnings

August 03, 2023

Ozona Organics Liquid Probiotics Recalled Due to Risk of Microbial Contamination

On August 1, 2023, Ozona Organics, LLC recalled certain lots of its probiotic supplement, Ozona Probiotics for Digestive Health, also labeled as GoHealthy Probiotics for Infants, Toddlers, and Kids and GoHealthy Probiotics for Infants, Kids, Men, and Women, due to the ...

Recalls & Warnings

June 30, 2020

FDA Warns Seller of Alpha Lipoic Acid, Berberine, and More

On June 18, 2020, the FDA issued a warning letter to Only Natural, Inc. dba Bio Nutrition, Inc.

Recalls & Warnings

February 22, 2021

Canadian Creatine Recalled for Dangerous Levels of Vitamin D

On February 21, 2021, the Canadian company Genex Nutraceuticals recalled one lot of Perfect Sports Core Series Pure Creatine (also known as Creatine Powder) because it "contains vitamin D that is not listed on the label, at dangerous levels.

Recalls & Warnings

August 25, 2022

Oregon’s Wild Harvest Warned by FDA for Manufacturing Violations

On July 8, 2022, the FDA issued a warning letter to Oregon’s Wild Harvest, Inc.

CL Answer

What are the health benefits of black cumin seed (black seed) oil?

Find out if black seed oil has health benefits, such as lowering blood pressure or cholesterol, asthma, weight loss, and others. Dosage, forms, including black seed oil and black seed powder, safety information, using black seed oil in foods and more. ConsumerLab.com's answer explains.

Black seed oil benefits -- bowl of black cumin seeds and bottle of oil

CL Answer

Do any supplements help for flu?

Which supplements may help prevent or reduce symptoms of colds or the flu, including vitamin D, ginseng, NAC, and elderberry.

Supplements for Flu -- women with the flu sitting on couch with tissues, thermometer, warm drink

Recalls & Warnings

October 30, 2020

Seller of Vitamin C, Vitamin D, Ashwagandha, and More Warned for COVID-19 Claims

On October 23, 2020, the FDA issued a warning letter to Predator Nutrition for selling the products Elixir, Salidroside, Unbreakable, Vitamin C + Bioflavonoids & Rosehip, Vitamin D3, and Ashwagandha with unsupported claims that they can treat coronavirus (COVID-19).

Recalls & Warnings

December 22, 2021

FDA Warns Seller of Liquid Magnesium, B-12, Berberine & More

On December 9, 2021, the FDA issued a warning letter to Wholly Liquid Nutritional Supplements LLC because it found statements on the company's website and social media about its products, including SpiroLaze, BioLaze, LiquiLaurin, VIT-B12, DeStress, and Omega Plus, to be ...

Recalls & Warnings

December 09, 2021

FDA Warns Seller of Curcumin, Lion's Mane, Quercetin & More

On November 9, 2021, the FDA issued a warning letter to Synaptent, LLC because it found statements on the company's website about its products, including Berberine HCL, Curcumin, Lion's Man, Milk Thistle, Quercetin, Boswellia Serrata Extract, and Garlic Extract to be ...

Recalls & Warnings

June 02, 2018

FDA Warns Seller of Cough Suppressant & Grape Seed Supplements

On March 29, 2018, the FDA issued a warning letter to Yoder's Good Health Products following a facility inspection which found a number of the company's products, including Respiratory & Cough Formula and Life Drops to be adulterated because they were prepared, packed, or ...

Recalls & Warnings

July 12, 2013

Herbal Supplement Company Warned For Drug Claims, Manufacturing Violations

On June 18, 2013, the FDA issued a warning letter to Herbs of Light, Inc.

Recalls & Warnings

June 13, 2013

Seller of Cardio, Immune, Greens Supplements and More Warned For Drug Claims

On May 29, 2013, the FDA issued a warning letter to dietary supplement company Nature's Answer, following a review a the company's website, www.naturesanswer.

Recalls & Warnings

November 07, 2015

Seller of "NaturalDoctor" Vitamin C, Echinacea and More Warned for Manufacturing Violations

On October 16, 2015, the FDA issued a warning letter Sound Healing Arts, PC, dba Grounds for Tea, LLC, following a facility inspection which found the company's products, including  NaturalDoctor Vitamins C & K3, NaturalDoctor Goldenseal & Echinacea Plus, NaturalDoctor Centella ...

Recalls & Warnings

September 16, 2015

Herbal Extracts Recalled

On September 15, 2015, Iowa Select Herbs, LLC issued a recall of numerous herbal exacts following a permanent injunction which required the company to stop selling supplements.

Recalls & Warnings

March 22, 2016

NOW Foods Recalls Ginkgo & Other Supplements

On March 18, 2016, NOW Foods issued a recall of the following dietary supplements due to errors on the labels: 

Recalls & Warnings

March 28, 2011

FDA Cracks Down on Violators of Supplement Manufacturing Rules

In February and March 2011, the U.S. FDA posted Warning Letters sent, respectively, to a distributor of dietary supplements and a supplement manufacturer for violations of current Good Manufacturing (GMP) rules.

Recalls & Warnings

August 27, 2013

Immune Supplement Recalled Due To Undeclared Milk

On August 23, 2013, Reaction Nutrition, LLC issued a voluntary recall of immune support supplement LIVE CLINICAL 90 CAPS because it contains undeclared milk.