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Increased Heart Risk


Although a direct link to heart attack has not been made, researchers recently showed that intake of phosphatidylcholine, a major component of lecithin, temporarily raises blood levels of the compound TMAO. This is of concern because a 3-year study by the same researchers showed that people with the highest blood plasma levels of TMAO -- above 6 µM (micromoles) -- were 2.5 times as likely as those with the lowest levels (under 2.5 µM) to suffer a heart attack or other major adverse cardiovascular event (Tang, New Eng J Med 2013). TMAO is produced from the choline in phosphatidylcholine by the actions of microbes in the gut and enzymes in the liver. TMAO appears to advance atherosclerosis (hardening of the arteries) by reducing the normal clearing of cholesterol.

The researchers showed that eating two hard-boiled eggs (which contain about 500 mg of total choline) temporarily raised TMAO blood plasma levels, on average, from about 4 µM (micromoles) to close to 8 µM.

The data suggest that excessive routine consumption of dietary phosphatidylcholine and choline should be avoided. This may be advisable anyhow, as foods rich in these compounds (egg yolk, liver, beef, and pork) are also typically high in fat and cholesterol. The researchers note that a vegetarian or high-fiber diet can reduce total choline intake. Unless medically necessary, it may also be prudent to avoid long-term supplementation with high doses of lecithin, phosphatidylcholine, and/or choline.

(A similar connection with TMAO and cardiovascular disease risk was recently made by the same researchers for L-carnitine from red meat and, possibly, from supplements with L-carnitine, including acetyl-L-carnitine -- see the Concerns and Cautions section of the Acetyl-L-Carnitine Supplements Review>>).

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May 2, 2016

O, my!!! Adele DAvis in the 1960s cited studies showing lecithin help PREVENT artheriosclerosis... my my... glad I checked.

January 5, 2020

Oh yes, I immediately thought of Adele Davis too. I used to make up her special Pep Up drink with brewers yeast, lecithin etc. I must admit, it did give me energy...
Unfortunately, dietary research was not of the same standard as today.

June 29, 2020

I was an Adelle Davis baby - my mother was a complete nut on the subject, but it lead to my being obsessed about food as medicine as an adult. Food research is indeed much more advanced now than it was then, but expert opinion is just as divided if not more, especially on the subjects of fats, cholesterol, grains, milk, and now even killer vegetables such as tomatoes. You really have to do a LOT of research to figure out which branch of the "facts" you want to follow.

September 27, 2020

Adele Davis usually tells about the studies that led to her conclusions. But if the word here on eggs is correct, I'm going to miss my two -egg breakfasts, 2 deviled eggs for lunch, and custard for dessert at dinner. (Not all on the same days, however). Eggs are my go-to convenience food.

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