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Glutathione Review 2024
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Which is the best glutathione supplement?

  • What is glutathione?

    Glutathione (which is the same as “L-glutathione” and “reduced” glutathione) is a peptide that our bodies produce and use as an antioxidant. You can also get it from supplements, but most of it is broken down by enzymes in the gut into amino acids, such that only long-term use of large amounts (500 mg or more) appears to modestly raise glutathione levels. It can also be taken as a supplement as a liposomal formulation or in the form of S-acetyl-glutathione, although these also appear to have limited impact on raising glutathione levels in the body. (See What It Is).
  • What does glutathione do?

    Although glutathione plays an important role in the body as an antioxidant, studies have yet to prove that supplementing with it is useful for any condition, including Alzheimer's disease, type 2 diabetes, or skin lightening. (See What It Does).

  • We purchased and tested the quality of 11 popular glutathione and S-acetyl-glutathione supplements. One failed our tests for providing only 81% of its listed amount of glutathione. Among products found be accurately labeled (all of which also passed our tests for contamination with heavy metals such as lead), we selected Top Picks for glutathione overall, liposomal glutathione, and S-acetyl glutathione, each representing high quality, transparent labeling, and lower cost relative to comparable products.
  • Is glutathione safe to take?

    Glutathione is generally well-tolerated but can cause mild gastrointestinal side effects and, possibly, skin flushing. Long-term safety studies, however, have not been conducted (see Concerns and Cautions).

Make sure you're choosing the best glutathione or S-acetyl-glutathione supplements approved in our tests!

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Alphabetical list of glutathione and S-acetyl-glutathione supplements compared in this review

View Larger Image Apex_Energetics_Nutritional_Complexes_Trizomal_Glutathione-Glutathione-small.png

Apex Energetics Trizomal Glutathione (K-122)

View Larger Image Bulletproof_Glutathione_Force-Glutathione-2024-small.png

Bulletproof Glutathione Force

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Designs For Health S-Acetyl Glutathione Synergy

View Larger Image Dr_Mercola_Liposoal_Glutathione-Glutathione-2024-small.png

Dr. Mercola Liposoal Glutathione

View Larger Image Jarrow_Formulas_Glutathione_Reduced-Glutathione-2024-small.png

Jarrow Formulas Glutathione Reduced

View Larger Image Life_Extension_Glutathione_Cysteine_and_C-Glutathione-2024-small.png

Life Extension Glutathione, Cysteine & C

View Larger Image NOW_Glutathione_500_mg-Glutathione-2024-small.png

NOW Glutathione 500 mg

View Larger Image Pure_Encapsulations_Liposomal_Glutathione-Glutathione-2024-small.png

Pure Encapsulations Liposomal Glutathione

View Larger Image Quicksilver_Scientific_Glutathione-Glutathione-2024-small.png

Quicksilver Scientific Liposomal Glutathione - Lemon Mint

View Larger Image Swanson_L-Glutathione-Glutathione-2024-small.png

Swanson L-Glutathione

View Larger Image Thorne_Glutathione-SR-Glutathione-2024-small.png

Thorne Glutathione-SR

You must be a member to get the full test results along with's recommendations and quality ratings. You will get results for 11 popular glutathione and S-acetyl-glutathione supplements selected by In this comprehensive review, you'll discover:
  • Which glutathione and S-acetyl-glutathione supplements failed testing and which passed
  • CL's Top Picks, representing the best quality glutathione and S-acetyl-glutathione supplements at lowest cost
  • How various forms of glutathione (e.g., L-glutathione, "reduced" glutathione) do or do not differ and if it's worth paying more for special formulations, including liposomal glutathione (such as Setria)
  • Glutathione and S-acetyl-glutathione supplements dosing for treating specific conditions
  • The best way to take glutathione and S-acetyl-glutathione supplements
  • Glutathione supplements safety and side-effects

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Additional Information
Tested through CL's Quality Certification Program prior to, or after initial posting of this Product Review.