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D-mannose (also called just mannose) has been shown in preliminary studies to reduce the rate of recurrent urinary tract infections. For more about these studies, including dosage, see the full answer >>

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May 31, 2020

I'd certainly like to see more clarity re: D-mannose. Not whether or not it works; I think that if scientists disregard the massive amount of anecdotal reports, they're just plain crazy (or working for interests that only want a more expensive solution that they can control). I first recommended d-mannose to a friend who was out of solutions; after multiple occurrences of UTIs, her doctor could only suggest the fluoride drugs (avoid at all costs!!!) and she was in constant pain. I suggest a teaspoon of d-mannose every few hours, and within 1 day her symptoms disappeared, and subsequent urine tests showed the infection was gone. My Mom used d-mannose regularly to avoid the vast majority of [prior-pattern] UTIs until she passed at age 99.

But the clarity I'm seeking is around its metabolism. I've seen multiple references from respected sources saying that d-mannose isn't metabolized by the body; if that's the case, why is there any kind of warning for diabetics (is this just another form of control?)?

August 21, 2019

I spent heaps of time researching D-Mannose. I found Washington Uni is performing human trials currently with this sugar. I emailed and offered to participate. I also reviewed the specs for participation. During my research, I found pure D-Mannose powder made in the US. This company participates with at least 100 science entities who require an excellent product for trials. I won't mention the name as I have no connection with them other than as a customer. My fears are twofold: my recurrent UTIs will make me antibiotic resistant; and, I do not want to destroy my microbiome. I buy only quality whole foods, as I am vegan and most particular. I started the pure D-Mannose powder August 1 with no side effects whatsoever, nor do I have a recurrence. The powder easily dissolves in water. I drink this in the evening. It is important that one has a culture taken to see if E Coli is the cause of a UTI. From all my copious research, D-Mannose targets E-Coli that is able to cling to the bladder wall. So, one has to know the cause of the UTI before considering D-Mannose.

November 13, 2019

I want to add here that my research provided information about UTI vaccines available in Switzerland under the following names: Uro Vaxum, Uro Vac, and ExPEC4V. These are discussed in a PubMed article readily available on the web (Vaccines for the Prevention of Recurrent Urinary Tract Infections: a Systematic Review, dated May 2019). These UTI vaccines are marketed in Europe and Canada. It is my hope that the US moves swiftly on a vaccine.

July 29, 2021

I'd rather stick to what's natural and would like more info on the use of D-Mannose when available.

August 5, 2018

This is purely anecdotal, but several years ago I owned a German shepherd who unfortunately inherited the gene for degenerative myelopathy.....multiple sclerosis in dogs. As the disease progresses up the spine, the bladder becomes either flaccid or tight, either of which can cause a UTI. My vet recommended that I give him D Mannose daily and he never was affected with an infection or with any side effect.

March 7, 2016

My urologist suggested that I try d-mannose after a year of battling E. Coli urinary tract infections treated with antibiotics followed by the UTI returning. The physician prescribed an antibiotic as usual, but told me that I should try the d-mannose powder 2 x daily. I can't believe how quickly the infection cleared up and remained clear! I'm going on my second month of no antibiotics and no UTIs. I'm not big on supplemental cures, but this was recommended by my urologist (UCSan Diego Health Care) so I tried it. I'm a believer!

July 6, 2017

Me too!

August 23, 2021

Mannose was just recommended to me by my urologist at UC San Diego Heatlh care

June 10, 2015

Excellent product for keeping bacterial infection in urinary tract at bay. I usually notice results within 12 hours, and complete absence of symptoms within 24-36 hours.

May 6, 2015

I have had several UTI's in the past because of prostate problems. I have recently been taking a cranberry extract supplement once a day for about 2 years and haven't had any UTI's since.

May 6, 2015

I have a neurogenic bladder from multiple sclerosis and D-Mannose is the one supplement I ALWAYS take. I've been taking it for years and it rescued me from the horrid antibiotic/yeast infection UTI cycle.

When I take my d-mannose, I never get a full-blown UTI. I do not understand why the physicians do not make more women aware of this. They usually dismiss it and pull out their prescription pads! Maybe with these new findings, the physicians will feel more confident to recommend d-mannose for UTI management.

Don't get me wrong, when a full-blown UTI occurs, antibiotics are needed. But the d-mannose keeps me off chronic use of them.

May 6, 2015

D Mannose and Cran Naturelle have always worked for my family and friends at the first sign of symptoms. Takes care of it everytime.

May 6, 2015

I would recommend trying D-mannose for UTI. 60 year old male, recent UTI became quite painful. D-mannose every two hours, normal dose on bottle and within hours noticeable relief. Whenever symptoms recurred since then a day or so of D-mannose twice a day abates the symptoms. Bear in mind that it only helps with Escherichia coli (E. coli) infections, which are the majority of UTI infections.

Best thing is no side-effects that I noticed. It is best to not take high doses for an extended time, to protect the kidneys or if you are prone to diabetes (see The body does not metabolize much of D-mannose so it passes out through the urine, taking the E. coli with it.

May 6, 2015

MY mother suffered from recurrent UTIs until she started using D Mannose. It stopped her infections and relieved her from the yeast infections that the antibiotic regimen seemed to always inflict.

May 6, 2015

ellura (36 mg PAC DMAC) is far and away the best product to prevent recurrent UTIs. It is a medicine in France but is a supplement in the U.S. It is made from the active ingredient of the cranberry, the A-type Proanthocyanidin, found in the juice. ellura definitely a GREAT product!
May 28, 2015

Hi Kevin - We've included information about this product in the CL Answer about cranberry juice and supplements:

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