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Interactions Between Statins & Fish Oil Supplements

Reviewed and edited by Tod Cooperman, M.D. Tod Cooperman, M.D.
Initial Posting: 5/23/2014    Last Update: 9/19/2019

Question:
Is it true that taking a statin drug negates the benefits of taking fish oil supplements?
Taking Statins & Fish Oil -- fish oil capsules and stethoscope
Answer:
Although there is evidence that statins and other cholesterol-lowering drugs can alter the metabolism of omega-3 fatty acids in the body (reducing levels of DHA in the case of the drug fenofibrate, for example), this does not argue against taking fish oil when taking these drugs. In fact, taking fish oil can lower triglyceride levels and lower "bad" cholesterol levels when taken with cholesterol-lowering drugs. For more information, see the Cautions and Concerns section of the Fish Oil and Omega-3 Fatty Acid Supplements Review.

Learn More About Supplements and Statins:



When taking a statin drug like Lipitor or Crestor, are there supplements I should avoid or take? >>

I take ubiquinol to replenish CoQ10 depleted by my statin. I also take curcumin (from turmeric). Since they both manage free radicals, do I need to take the curcumin?  >>

Can I take cholesterol-lowering statin medication with green tea? >>

Can I take CoQ10 at the same time as my statin, or should I take them separately? >>

I read that statins can cause diabetes. Is this true also with red yeast rice?  >>

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COMMENTS
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Andrew16278   December 17, 2017
Statins appear to have anti-inflammatory properties (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59622/) and so does fish oil (https://www.ncbi.nlm.nih.gov/pubmed/16531187) although it is not exactly clear whether both act in the same way, especially given their molecular dissimilarity.
Inflammation is one of the older components of the immune system and was probably of greater importance in survival before the age of modern medicine. Also, as we age, inflammation tends to get a bit out of control, e.g., arthritis, cancer and cardiovascular problems.
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This CL Answer initially posted on 5/23/2014. Last updated 9/19/2019.
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