Although tablets should disintegrate in a short period of time in your stomach, not all do. ConsumerLab.com has found that about 5% of products sold as tablets don't disintegrate as fast as they should, and some fail to disintegrate at all.
So how do you know if the tablet you are taking is among those that don't dissolve properly?
Be aware that passing a disintegration test does not guarantee bioavailability — which depends on additional factors such as how well ingredients are absorbed.
Although you are unlikely to have disintegration issues with regular softgels and capsules, ConsumerLab.com has found issues with some enteric-coated (delayed-release) capsules and softgels.
(ConsumerLab.com uses USP standards for tablet disintegration (United States Pharmacopeia [USP] "Disintegration and Dissolution of Dietary Supplements" method <2040>
), which require uncoated and plain-coated tablets to disintegrate completely within 30 minutes. Enteric-coated (delayed-release) tablets and soft shelled capsules are required to disintegrate within one hour in simulated intestinal fluid after an initial hour in simulated gastric fluid during which they should remain intact.)