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CL Answer

Is topical menthol, such as Biofreeze, safe and effective for pain relief?

Menthol is commonly used in topical creams and gels for pain relief. Find out if it works and if it's safe.

Man applying menthol cream

CL Answer

Conolidine: Evidence for Pain Relief, Safety, and CONOCB2™ Products Explained

Find out if conolidine, the main ingredient in CONOCB2 Blend, offers natural pain relief without the side effects of opioids. Also learn about the top conolidine products available today.

Three commercial products that contain conolidine

Clinical Update

5/16/2023

Do Pain Gels Work?

Do menthol gels like Biofreeze provide effective pain relief and are they safe? Find out in our new article about topical menthol.

Clinical Update

6/09/2023

Menthol Rubs for Pain?

Do menthol rubs like Biofreeze and Vicks VapoRub really reduce pain, including diabetes-related nerve pain, and are rubs with capsaicin any better?

CL Answer

Supplements For Back Pain: What Helps, What's Hype

Some supplements may provide modest benefit for back pain, while others don't seem to work or haven't been evaluated for this use. Find out if supplements like collagen, devil's claw, PEA, pregnenolone, white willow bark, and others help.

Man holding lower back due to low back pain

CL Answer

Do any supplements, like Nervive, help with nerve pain, like sciatica, diabetic neuropathy or postherpetic neuralgia?

Find out which supplements for nerve pain, including fish oil and alpha-lipoic acid, are effective for sciatica, diabetic neuropathy, or postherpetic neuralgia.