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Product Reviews (3)

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CL Answers (15)

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Recalls & Warnings (29)

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Clinical Updates (16)

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Vitamin E and Liver Cancer

A study has shown a dramatic decrease in the risk of liver cancer among people taking vitamin E supplements or getting higher amounts of vitamin E from their diets. But don't necessarily rush out to get vitamin E. Read the details in the update to the Vitamin E Supplements ReviewMore >>

Cancer Findings with Natural Vitamin E

Clinical studies have raised doubts, and even concerns, about the relationship between vitamin E supplements and cancer. However, recent studies in animals suggest the tocopherols found in natural forms of vitamin E may help prevent cancer -- although the results are preliminary. For more about this, and our tests of vitamin E supplements, see the updated Vitamin E Supplements ReviewMore >>

Vitamin E Risk

A study of healthy men who had taken a high-dose vitamin E supplement for several years showed a 17% increase in the risk of prostate cancer compared to men who took a placebo. See the Vitamin E Supplements Review for details, extensive information about vitamin E, and our quality ratings of vitamin E supplements.  More >>

Vitamin E Helps Alzheimer's Patients

A new study suggests that high-dose vitamin E can help people with Alzheimer's disease retain their ability to perform activities of daily living (such as dressing) for several months longer than those given placebo, reducing caregiver time. A similar dose of vitamin E has been shown in other studies to slow the progression of the disease in some people and to reduce the rate of conversion to Alzheimer's among people with mild cognitive impairment. For details -- including the dose and form of vitamin E used and our tests of supplements on the market which can provide this dose -- see the update to the Vitamin E Supplements Review >>

Do We Need More Vitamin E?

A study recently suggested that many Americans don't get optimal intake of vitamin E from their diets. A closer look at this study, however, indicates that most people in the U.S. shouldn't worry. For details see the ConsumerTips section of the Vitamin E Supplements Review >>

Vitamins C & E Blunt Exercise Effect

A recent study found that giving high-dose vitamin C or vitamin E to people involved in intensive exercise training blunted cellular changes thought to be important for improving muscular endurance. These and similar results recently reported with resveratrol raise concerns about high-dose antioxidant supplementation during exercise training. For details, see the updates to the "Concerns and Cautions" sections of the Vitamin C Supplements Review >>  and the Vitamin E Supplements Review >> 

Vitamin E, Selenium Can Increase Cancer Risk

In some men, taking high doses of vitamin E or selenium may double the risk of developing high-grade prostate cancer, according to a recent analysis. For details, including the dose, see the updates to the Vitamin E Supplements Review >> and the Selenium Supplements Review >>   

Can Vitamin E and/or Selenium Help Prevent Cataracts?

A study in older men in the U.S. found that taking large daily doses of vitamin E and/or selenium did not significantly reduce the risk of developing cataracts. But could the dose have been too high to be helpful? Other research has shown that "less is more" when it comes to antioxidant supplementation for cataracts. For more information, see the updates to the Vitamin E Supplements Review and the Selenium Supplements Review >> 

Vitamin E/Selenium & Alzheimer's

A long-term study among men in the U.S. found that giving high doses of vitamin E and/or selenium did not significantly affect their risk of developing dementia. The study was part of a larger study which found that these supplements increased the risk of prostate cancer, type 2 diabetes, hair loss, and dermatitis. For details, see the "Alzheimer's disease/dementia" section of the Selenium Supplements Review >>

Latest Supplement Recommendations

New draft recommendations on vitamin and mineral supplement use were published this week by the U.S. Preventive Services Task Force. The recommendations apply only to healthy adults without nutritional deficiencies. They focus only on the use of supplements for the prevention of cardiovascular disease and cancer at doses not exceeding tolerable upper intake levels. The recommendations are based on existing science and are generally consistent with information already presented in's Product Reviews.  We have summarized the recommendations below, with links to more information in's reports:

- Beta-Carotene and Vitamin E:  Supplementation with either does not provide a benefit. Vitamin E does not pose a risk of harm, but beta-carotene increases the risk of lung cancer in people at risk for lung cancer.

- Other Single Vitamins, Minerals, Pairs, and Multivitamins: There is inadequate evidence regarding a benefit or a risk of harm.

The task force stressed that at excessive doses (above tolerable upper intake levels) there is evidence of harm with supplementation, such as with vitamin A and vitamin D

Antioxidants: Too Much of a Good Thing?

A new, long-term study of Americans found the risk of dying over the course of the study (about 14 years) was lowest when antioxidant levels in the blood were above the lowest levels (the bottom 20% of the population). However, for people in the top 20% of blood levels for vitamins A and E, the risk of death increased compared to people with moderate levels. For selenium and beta-carotene, there was no significant difference in the death rate between moderate and high levels, although for vitamin C some additional benefit was seen at high, but not the highest, levels.
The results suggest that antioxidant supplements may be useful for those who are nutritionally deficient, but, as noted by the researchers, "beyond a certain threshold, higher levels do not lead to additional benefit, and may potentially be toxic." More details (including specific serum levels) are found in the linked updates to the following reviews, which include our test results and quality ratings of products:

Supplements During Chemotherapy?

If you are getting chemotherapy, experts now recommend avoiding acetyl-L-carnitine. Also, see what they have to say about using alpha-lipoic acid, vitamin B-12 and vitamin E.

Additional Nutrients For the Brain

An new study found that various nutrients and fats in the blood correlate with better brain functioning and brain volume in the elderly (mean age of 87). Higher levels of B vitamins and vitamins C, D, and E, as well as marine omega-3 fatty acids (EPA and DHA) appeared helpful. On the other hand, higher levels of trans-fats (from hydrogenated oils) had a negative impact. You can learn more about each of these nutrients in our various reports. An abstract of the study is online.

Exercise Benefit Lost With High-Dose Vitamins

Older men asked to perform resistance (strength) training for 12 weeks showed less gain in bone density if they were given high daily doses of vitamins C & E than if they were given a placebo. This is not the first time that  high-dose antioxidant supplements have been shown to reduce benefits from exercise. For details, see the "Concerns and Cautions" section of the Vitamin C Supplements Review >>

Caution With Antioxidants

A new study suggests it might be risky to take antioxidant supplements during cancer treatment. We have added this important information to our answer to the following question: Can supplements with antioxidants like beta-carotene and vitamins A and E cause you to die sooner?

Vitamin C Blunts Exercise Benefits

If you are trying to build muscle with resistance exercise, go easy on vitamins C and E, according to a recent study. Get the details in the Concerns and Cautions section of the Vitamin C Supplements Review.

News Releases (13)

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