I have heard that caffeine can interfere with the benefits of creatine supplementation. Is that true?
It is true that some evidence suggests caffeine can diminish the effectiveness of creatine. However, this negative effect appears to depend on whether caffeine is taken on a short-term or long-term basis. For details and more about the use of creatine, see the "What to Consider When Using" section of the Review of Muscle Enhancers (Creatine and Branched-chain Amino Acids) -- which includes our tests and comparisons of products.