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White Plains, New York, January 19, 2016 — SAM-e (S-adenosyl-methionine) is involved in the functioning of every cell in the body and, as a supplement, it has been found to be helpful in reducing the pain of osteoarthritis as well as improving mood in major depression. But which SAM-e supplements are best? To find out, recently selected 10 SAM-e supplements and tested them to see whether they contained their claimed amounts of SAM-e, and if enteric coatings (which protect SAM-e in the stomach) functioned properly. In 2014, $125 million of SAM-e supplements were sold in the U.S. according to Nutrition Business Journal. (CL) discovered that one product contained only 77% of its listed amount of SAM-e. CL also determined which products provided the best value, as SAM-e can be expensive, costing as much as $3 for a 400 mg daily dose. Among the products which passed testing (including three products tested through CL's voluntary Quality Certification Program), ConsumerLab identified one which provided 400 mg of high-quality SAM-e for just 51 cents. The product was enteric-coated to protect SAM-e from stomach acid and sold in a blister pack to prevent spoilage from moisture, as SAMe is a sensitive compound.

The test results are now available in's SAM-e Supplements Review at This report includes clinical information about how SAM-e is used and tests and comparisons for the following products: Cellfood SAM-e Liquid Formula, CVS pharmacy SAM-e, Designs For Health SAMe, Doctor's Best Double-Strength SAMe, GNC SAM-e, Nature Made SAM-e Complete, Nature's Sunshine SAM-e, NOW SAMe, RiteAid Pharmacy SAM-e 200 mg, Spring Valley (Walmart) SAMe, Swanson Ultra High-Potency SAMe, The Vitamin Depot Double Strength SAM-e, and Vitacost SAM-e.

Founded in 1999, is a leading provider of consumer information and independent evaluations of products that affect health and nutrition. Membership to is available online and provides immediate access to reviews of more than 1,000 products from over 400 brands. The company is privately held and based in Westchester, New York. It has no ownership from, or interest in, companies that manufacture, distribute, or sell consumer products.

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