- What is SAMe? SAMe is a compound which naturally occurs in the human body (see What It Is).
- Health benefits of SAMe: As a supplement, it has two major uses (see What It Does).
- It is effective as a treatment for osteoarthritis and associated joint pain, stiffness, and inflammation. It may take longer to work than leading anti-inflammatory drugs but the benefit seems to last longer with fewer side effects.
- It is an effective antidepressant in treating major depression and may be particularly useful for people who do not respond to prescription treatment.
- How to choose a SAMe product: Choose SAMe products carefully because it is an expensive ingredient (companies may put in less than listed) and is sensitive to breakdown if exposed to heat or moisture. Look for a product packaged in a blister pack (see ConsumerTips™). Generally, it should also have an enteric-coating to protect it from degradation by stomach acids which can render it ineffective. (See Quality Concerns)
- What did CL's tests of SAMe find? Among the 10 products selected by CL for testing, one contained only 76.5% of its listed SAMe and provided an unusually small dose. (See What CL Found).
- How much SAMe should I take? Daily dosage shown to be effective in clinical trials ranges from 800 mg to 1,600 mg of SAMe (See ConsumerTips™ for details).
- Best SAMe supplements: See Top Picks for products which passed testing, were enteric coated, and provided SAMe at lowest cost. All of these are packaged in blister packs for stability.
- SAMe safety and side effects: SAMe should not be used by people with bipolar disorder (See Concerns and Cautions for more information.)
SAMe (S-adenosyl-methionine) Supplements Review
Choose the Best SAMe Supplement. CL Tests Reveal Big Differences in Quality and Cost.
SAM-e supplement brands compared in this review
Cellfood SAM-e Liquid Formula
CVSｮ pharmacy SAM-e
Designs For Health SAMe
Doctor’s Best Double-Strength SAMe
GNC SAM=e 400
Nature Made SAM-e Complete
Nature's Sunshine SAM-e
Nature's Trove SAMe 400 mg
RiteAid Pharmacy SAM-e 200 mg
Spring Valley [Walmart] SAMe
Swanson Ultra High-Potency SAMe
The Vitamin Depot Double Strength SAM-e
- Which SAM-e supplements passed or failed testing
- Direct comparisons and quality ratings of SAM-e supplements, including cost comparisons showing you can pay anywhere from 51 cents to over $3 for the same amount of SAM-e -- it pays to compare prices
- What SAM-e can and cannot do for your health
- Tips on buying SAM-e and how to properly store it
- SAM-e dosage for different conditions
- Concerns, drug interactions, and potential side-effects of SAM-e
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