What are the best supplements for depression and anxiety?

I was taking methylfolate for depression (prescribed as Deplin from Brand Direct Health) along with Latuda (for depression) and Depakote (for bipolar) and I had the side effect of nystagmus, so I stopped taking it as recommended by my psychiatrist. It's unfortunate because it was helping with my depression. I have no affiliation or financial interest with any of these products I mentioned or a competing product.

Be careful mixing with meds! My daughter-in-law who has bipolar disorder started taking kava and soon afterward was nearly hospitalized. Altho’ it may be a coincidence, she feels the kava could have interfered with her prescription medication.

I see that fish oil high in EPA may reduce anxiety. Can you specify what percent EPA would be high and what dose has been shown to be effective?

I was taking Ashwaganda for mild depression it caused me to have an arythmia in my heart, felt awful so I came off of it and the arythmia has subsided!

A relative uses Venetron (150 mg) for depression when needed. It makes a huge difference in lowering what appears to be situational depression. Some capsules sold are 50 mg. However, the manufacturer said 150 mg was best. It doesn't cause sleepiness like other products.

He's also been using SAMe (400 mg) daily for years and takes it about 6 pm. When he awakes in the morning, he is ready to get going for the day. Because there are concerns about SAMe increasing Homeocysteine, he takes a 750 mg capsule of Trimethylglycine daily. Recently, he had his blood tested for the Homeocysteine and the result was within the normal range. In fact, it was on the lower side.

My relative has suffered from a severe depression for four years. No prescription medication had any significant effect. During this time she also tried without much success most supplements including 5HTP that claimed to be helpful for such condition. The real relief came when she start taking Seratonin formula [from Allergy Research] and SAMe. The Seratonin formula includes both 5HTP and 5-MTHF. This brought an improvement in about 3 weeks, and helped her to get completely out of the medication [by gradually reducing the dosage] in about four months. At this, she was taking only one Seratonin capsule and one caplet of SAMe, which was about one third of recommended dosages on their labels (there was a concern of taking larger dosages of these supplements simultaneously with an antidepressant).

How about CBD from hemp for anxiety/depression?

Lactium, a bioactive milk peptides have since been shown to act on the brain's GABA-A receptors.

I use Swanson magnolia bark. I first heard of it from the Dr. Oz. show. Have used it for several years and works pretty good. I used to take Zoloft but had too many side effects. No side effects with the magnolia bark.

I'm a therapist and work with women. I suggest to all my clients struggling with depression to take a look at the research on Omega3 augmentation (or as a stand alone) and to have their thyroid and D3 levels checked out. I've seen huge changes in my clients disposition when the correct blend and amount of Omega3s are added and their Ds levels are well above the bottom of the range. Choices for D3s and Omega3s have been researched by me on Consumerlab as I want my clients to get the purest and best product for their individual need.

By using NAC nightly I find I sleep much better and have stopped taking Prozac, after many years of use!

Having used all of the above I can say that kava has a far more profound stress reducing effect than any of these.