What are the best supplements for depression and anxiety?

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Probiotic for Depression?

Medically reviewed and edited by Tod Cooperman, M.D.

Written by Amy Malec

Updated March 24, 2025 ⓘ

Best Supplements for Depression and Anxiety -- sad young woman sitting on couch, looking toward the window

Answer:

A wide variety of natural supplements have shown some benefit in reducing depression and/or anxiety. Certain vitamin and mineral deficiencies can also cause depression.

Sign in to learn more how the following relate to depression and anxiety: Fish oil, krill oil, CBD oil, probiotics, prebiotics, curcumin (from turmeric), saffron, 5-HTP, St. John's wort, SAMe, DHEA, Rhodiola rosea, folic acid, L-theanine, ashwagandha, N-acetyl cysteine (NAC), melatonin, valerian, kava, palmitoylethanolamide (PEA), apple cider vinegar, B vitamins, vitamin D, magnesium, glucosamine, carnosine, beta-alanine, and collagen supplements.

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