Diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan) and other benzodiazepine drugs to treat anxiety and insomnia can be affected by taking certain supplements. For example, some supplements can increase the sedative effects or the risk of depression or impairment associated with these drugs.
Supplements like multivitamins may also contain added ingredients, like citrus bioflavonoids, which can potentially increase the effects of these drugs.
Grapefruit juice may also increase the effects of benzodiazepines and should be avoided.
On the other hand, certain supplements may be beneficial for people taking benzodiazepines.
Some side effects of benzodiapepines may increase when used with melatonin.