Diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan) and other benzodiazepine drugs to treat anxiety and insomnia can be affected by taking certain supplements, which may increase the sedative effects or the risk of depression or impairment associated with these drugs.
For example, grapefruit juice may increase the effects of benzodiazepines by blocking an enzyme that helps break down these medications and should be avoided.
Kava may also prevent the breakdown of benzodiazepines, as well as increase the sedative effects of these drugs.
Supplements like multivitamins may also contain added ingredients, like citrus bioflavonoids, which can potentially increase the effects of these drugs.
Some side effects of benzodiazepines, such as drowsiness, may increase when used with melatonin.