Initially Posted: 09/23/2016
St John's Wort Supplements Reviewed By

Alphabetical list of St. John's wort supplement brands compared in this review


Vitamin Shoppe St. John's Wort Extract


Nature's Way Perika St. John's Wort


Gaia Herbs St. John’s Wort Flower Buds & Tops


Planetary Herbals Full Spectrum St. John’s Wort


NOW St. John's Wort


Shaklee MoodLift Complex


Standard Process MediHerb St. John's Wort


Swanson St. John's Wort


Vitacost St. John's Wort Extract


Whole Foods St. John's Wort

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Does St. John's wort work? Yes, extracts of St. John's wort have been shown to be effective in treating mild to moderate forms of major depression. However, discovered that 6 out of 10 herbal supplements did not meet quality standards.  The biggest problem uncovered by was that many products did not contain the key plant compounds (hypericin and/or hyperforin) listed on their labels or expected based on the claimed amounts of St. John's wort. For example, the amount of hypericin found in daily servings of the supplements ranged from as little as 0.11 mg to 2.6 mg — a 20-fold difference. There was even greater variation in amounts of hyperforin, which ranged just 0.13 mg to 36.4 mg. This means you could be getting 280 times as much hyperforin from one St. John's Wort supplement than from another. These enormous differences are likely to impact the effectiveness of products. In short, some of the St. John's wort supplements on the market seem to have little of the herb while others provide substantial and clinically meaningful amounts.  All supplements were further tested for potential contamination with the heavy metals arsenic, cadmium, and lead. All pills were checked to be sure they would break apart properly to release their ingredients. You must be a member to get the full test results and independent quality ratings for St. John's wort supplements along with's recommendations of the best St. John's wort supplements. In this comprehensive review, you'll discover:
  • Which St. John's wort supplements failed testing, which passed, and which one is's Top Pick
  • Key differences in quality and ingredients among St. John's wort supplements
  • Which supplements are most like clinically-tested St. John's wort extract 
  • Price comparisons of St. John's wort supplements to help you find the best quality St. John's wort at lowest cost
  • Dosage recommendations for the antidepressant use of St. John's wort extracts and other herbal preparations
  • Concerns, cautions, side-effects and many drug interactions to avoid with St. John's wort

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