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St John's Wort Supplements Reviewed By

Alphabetical list of St. John's wort supplement brands compared in this review


Gaia Herbs St. John’s Wort Flower Buds & Tops


Nature's Way Perika St. John's Wort


NOW St. John's Wort


Planetary Herbals Full Spectrum St. John’s Wort


Shaklee MoodLift Complex


Standard Process MediHerb St. John's Wort


Swanson St. John's Wort


Vitacost St. John's Wort Extract


Vitamin Shoppe St. John's Wort Extract


Whole Foods St. John's Wort

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  • Do St. John's wort supplements help? Taking a supplement with the right type and amount of St. John's wort extract appears to be as effective in treating major depression of mild to moderate severity as standard antidepressant drugs, but with fewer side effects. St. John's wort is unlikely to help people who aren't truly depressed (See What It Does).
  • How much St. John's wort should I take? Clinical trials suggest that an effective dose is 900 mg per day of a concentrated extract standardized to at least 0.3% hypericin and/or 1% to 3% hyperforin (see ConsumerTips™).
  • Which St. John's wort product is best? Choose carefully, because 60% of the St. John's wort supplements selected for testing by did not contain expected amounts of one or more key plant chemicals. There was enormous range in these amounts, indicating that you could get, for example, as much as 280 times more hyperforin from one product than from another. Four products were Approved by, three of which are good choices and one of which was CL's Top Pick. Use our Results Table to see which products were, or were not, Approved, and to compare ingredients, test results, and prices.
  • Don't get hurt! Safety and side effects of St. John's wort: Although generally safe, St. John's wort can cause a range of side effects. It may cause mania in people with bipolar disorder and it may increase sensitivity to ultraviolet light, causing unexpected sunburn. Most importantly, St. John's wort can interact with a wide range of medications. See Concerns and Cautions for more information.

You must be a member to get the full test results and independent quality ratings for St. John's wort supplements along with's recommendations of the best St. John's wort supplements. In this comprehensive review, you'll discover:

  • Which St. John's wort supplements failed testing, which passed, and which one is's Top Pick
  • Key differences in quality and ingredients among St. John's wort supplements
  • Which supplements are most like clinically-tested St. John's wort extract 
  • Price comparisons of St. John's wort supplements to help you find the best quality St. John's wort at lowest cost
  • Dosage recommendations for the antidepressant use of St. John's wort extracts and other herbal preparations
  • Concerns, cautions, side-effects and many drug interactions to avoid with St. John's wort

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