Supplement Interactions with Antibiotics
Are there any supplements I should avoid when taking an antibiotic? Are there any that may be helpful?
Initial Posting: 5/31/2016    Last Update: 10/24/2019
Antibiotics can be affected by the supplements you take, and they can affect your ability to absorb certain vitamins and minerals.
The interactions will depend on the type of antibiotic you are taking. You can search for the specific antibiotic you are taking by name in the Drug Interactions section of our ConsumerLab.com.
Some of the most common antibiotics are listed below, followed by the supplements with which they can interact. Use the links for more details:
Amoxicillin (Amoxil, Trimox, Wymox): Bromelain, vitamin K
Cephalosporins (cephalexin (Cefanex, Keflex, Keftab, Biocef), cefdinir (Omnicef), etc.): Vitamin K
Fluoroquinolones (ciprofloxacin (Cipro), levofloxacin (Levaquin)): Calcium, magnesium, iron and zinc, fennel, Dong Quai, St. John's Wort
Tetracyclines (doxycycline (Bio-Tab, Doryx, Doxy-Caps), tetracycline hydrochloride (Achromycin V, Panmycin etc.): Calcium, magnesium, iron and zinc, Dong Quai, St. John's Wort, citrate (i.e. potassium citrate)
Trimethoprim/sulfamethoxazole (Bactrim, Cotrim, Septra, Sulfatrim): Folate, PABA (para-aminobenzoic acid), potassium, white willow, St. John's wort
Interestingly, some of the supplements noted above (folate and vitamin K) may, at times, be helpful when taking certain antibiotics, as can probiotics.
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