uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. Learn how to enable it here.


Last Updated: 09/21/2021 |
Digestive Enzyme Supplements Reviewed by

Alphabetical list of digestive enzyme brands compared in this review


Doctor's Best Best Digestive Enzymes


Dr. Tobias Digest Plant-Based Enzymes


Enzymedica Digest Gold with ATPro


Garden of Life Dr. Formulated Enzymes Organic Digest


GNC Natural Brand Super Digestive Enzymes


Healthy Origins Digestive Enzymes


NOW Optimal Digestive System


Pure Encapsulations Digestive Enzymes Ultra


Renew Life Digest Smart


Synergy Mega Digestive Enzymes


USANA Digestive Enzyme


ZenWise Health Daily Digestive Enzymes With Prebiotics + Probiotics

Be sure you choose the best digestive enzyme supplement, using CL's results and ratings! 
Isn't your health worth it?

See the Review Now

Join now at


  • What are digestive enzyme supplements? Digestive enzyme supplements contain enzymes such as bromelain, papain, amylase, cellulase and phytase, that can help you digest specific foods when you do not naturally produce enough enzymes. (See "What They Are" for a list of enzymes and the foods they break down.) They may also have other beneficial effects.
  • How to choose a digestive enzyme supplement: Choose a digestive enzyme supplement that lists enzyme activity units (such as PU, HUT, FIP, etc.), not just the amount of enzyme (such as milligrams) since that won't tell you how potent the enzyme is (See "What They Do"). Also, check that or another reputable independent 3rd party has verified the enzyme activity. As found in this Review, some products don't provide what they list (See "What CL Found")
  • Best digestive enzyme supplements? See our Top Pick among products "Approved" by
  • Digestive enzyme supplements safety and side effects: Digestive enzymes are generally well-tolerated but people with allergies to a specific enzyme source, certain medical conditions, or who take medications such as blood-thinners or diabetes drugs may need to avoid specific enzymes (See "Concerns and Cautions").
You must be a member to get the full test results for digestive enzyme supplements along with ConsumerLab's recommendations and quality ratings. You will get results for 12 supplements, including nine selected by and three others that passed the same testing through our voluntary Quality Certification Program. In this comprehensive review, you'll discover:
  • Which digestive enzyme supplements failed testing and which passed
  • ConsumerLab's Top Pick for digestive enzyme supplements
  • What different digestive enzymes do
  • The evidence for digestive enzymes for improving digestion and the absorption of nutrients, preventing indigestion, helping with conditions such as lactose intolerance and ulcerative colitis, and other uses such as reducing pain and inflammation
  • The amylase, lipase, and protease activity in each supplement and the other important enzymes they contain -- like lactase, alpha-galactosidase, cellulase, and phytase
  • How to choose an enzyme supplement and the best way to take them, including what enzyme units to look for on labels and dosage for specific uses
  • Potential side effects and drug interactions with digestive enzymes

Join to unlock the full report and get full access to over 1,300 reviews

See the Review Now

Join now at