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Yes, certain supplements may increase or decrease the effectiveness of clopidogrel (Plavix). This can increase the risk of bleeding or, conversely, increase the risk of blood clots. Clopidogrel is a "prodrug," meaning it must be broken down by the body to become active. Two liver enzymes, CYP3A4 and CYP2C19, are responsible for this. Consequently, supplements that interfere with these enzymes may reduce the effectiveness of clopidogrel, while supplements that that induce these enzymes may increase the activity of clopidogrel.

For details about which supplements can interfere with these anticoagulants, read the full answer.

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