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Overweight man holding his right side near his liver


Fatty liver disease (steatosis) is a condition in which extra fat is stored in the liver. The cause of one type of fatty liver disease, known as nonalcoholic fatty liver disease or NAFLD, is unknown but factors such as obesity, diabetes, or metabolic syndrome can increase the risk. NAFLD can be subdivided into nonalcoholic fatty liver (steatosis with no enlargement of liver cells) and nonalcoholic steatohepatitis or NASH (steatosis with enlargement of liver cells).

NAFLD may not cause serious problems, but it can lead to liver damage in some people. Fortunately, the condition can often be prevented or reversed with lifestyle changes such as dieting, exercising, and losing weight. Certain supplements, including vitamin E, delta-tocotrienol, vitamin C, fish oil, silymarin from milk thistle, curcumin, choline, vitamin D, reishi, a product called Glucevia, alpha-lipoic acid, SAMe (S-adenosyl-methionine), and bergamot, as well as foods such as probiotic yogurt, coffee, and extra virgin olive oil, have also been investigated.

Sign in to find out which, if any, of these supplements are safe and beneficial for fatty liver disease, which dietary considerations are considered most important for people with fatty liver disease, and which diet — the Mediterranean diet, ketogenic diet, DASH diet, or fasting diets — appears to have greatest evidence of benefit for fatty liver disease.

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August 3, 2021

I saw a video claiming reductions in blood biomarkers of non-alcoholic fatty liver disease from taking a citrus bergamot extract. I did a search on pubmed of "bergamot polyphenolic fraction NAFLD"; there were 7 hits. Here is one: The title is "Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome". I have no financial interest in any supplement.
August 9, 2021

We've added information about bergamot polyphenolic fraction in the answer above.

July 14, 2021

I appreciate that my reference to research on delta-tocotrienol was added.
July 14, 2021

Happy to help. Thank you for asking about it.

July 12, 2021

When it comes to vitamin E for NAFLD, you missed a huge study, at least related to delta-tocotrienol:
July 15, 2021

Thank you for bringing this to our attention. We've added information about delta-tocotrienol for fatty liver disease in the answer above:

July 12, 2021

I have heard that Alpha Lipoic Acid helps fatty liver (Not Alcoholic kind). Have you seen any real tests on this? Thank you.
July 15, 2021

Thank you for your question. We've added information about alpha-lipoic acid for fatty liver disease in the answer above:

July 11, 2021

I am surprised you did not mention Glucevia as that supplement has been recommended to help reverse or prevent fatty liver. I have no financial interest in Glucevia or any other supplement.
July 15, 2021

Thank you for your comment. We've added information about Glucevia for fatty liver disease in the answer above:

July 11, 2021

I have been taking green tea extract (NOW EGCg - 400mg) daily ever since I read a Medical Xpress item about a Penn State mouse study last year. I have also been taking Milk Thistle (Equate - 250mg) 1000mg/day for years, which makes my liver feel less stressed. I was diagnosed with fatty liver at 50 (I don't drink) 24 years ago, when I was at least 40 lbs. lighter. I haven't had it tested since.

August 8, 2021

My experience with green tea extract caused a significant rise in my liver enzymes.
When I removed it ( 30 day period) enzymes returned to normal.
( There are studies confirming my experience)

July 11, 2021

Wow. We are still on this dead end street. It's the food. It was always the food. Eat good food and exercise. Excessive supplements--like drugs--do not address the cause.

Carole 22914
July 13, 2021

My physician prescribed Ursodiol twice a day. LFTs are normal now. I know this is not a supplement, but I hope it is helpful

July 11, 2021

I'm surprised you didn't included tocotrienols in your review.
“Conclusion: This is the first (2013) clinical trial that showed the hepatoprotective effects of mixed palm tocotrienols in hypercholesterolemic adults with NAFLD.”

New Study Shows Tocotrienols Reverse Fatty Liver Disease, By Dr. Marilyn Arguillas, MD
Conclusion: (2018) d-Tocotrienol was safe, and it effectively improved aminotransferase levels and inflammatory and oxidative stress markers in patients with NAFLD. Large-scale randomized clinical trials are warranted to further support these findings.
July 15, 2021

Thank you for bringing this to our attention. We've added information about delta-tocotrienol for fatty liver disease in the answer above:

July 11, 2021

My wife has NAFLD with elevated liver enzymes (low level elevation). I put her on E Gems Elite Vitamin E 400IU. She take one daily and her Liver blood tests normalized. I am just a consumer. No financial interest in the company.

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