ConsumerLab.com uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. Learn how to enable it here.

About ConsumerLab.com

Last Updated: 10/19/2021 |
Alpha-Lipoic Acid Supplements Reviewed by ConsumerLab.com

Alpha-lipoic acid supplements compared in this review

5390_small_AlphaBetic-AlphaLipoicAcid-Small-2016 (1).jpg

alpha betic Alpha Lipoic Acid

5391_small_Bronson-AlphaLipoicAcid-Small-2016 (1).jpg

Bronson Laboratories Alpha Lipoic Acid

5392_small_CountryLife-AlphaLipoicAcid-Small-2016 (1).jpg

Country Life R-Lipoic Acid

5601_small_GNC-AlphaLipoicAcid-Small-2017 (1).jpg

GNC Alpha Lipoic Acid 600 mg

5393_small_JarrowFormulas-AlphaLipoicAcid-Small-2016 (1).jpg

Jarrow Formulas Alpha Lipoic Sustain 300 with Biotin

5394_small_Natrol-AplhaLipoicAcid-Small-2016 (2).jpg

Natrol Alpha Lipoic Acid 600 mg

Nature's Bounty Alpha Lipoic Acid

5395_small_NaturesSunshine-AlphaLipoicAcid-Small-2016 (1).jpg

Nature's Sunshine Alpha Lipoic Acid

5396_small_NOW-AlphaLipoicAcid-Small-2016 (1).jpg

NOW Alpha Lipoic Acid

5397_small_OL-AlphaLipoicAcid-Small-2016 (1).jpg

Olympian Labs Incorporated Alpha Lipoic Acid Naturopathic 400 mg

5398_small_OrthoMolecularProducts-AlphaLipoicAcid-Small-2016 (1).jpg

Ortho Molecular Products Lipoic Acid

5399_small_PureEncapsulations-AlphaLipoic-Small-2016 (1).jpg

Pure Encapsulations Metabolic Xtra

Puritan's Pride Alpha Lipoic Acid 300 mg

5400_small_RadiancePlatnum-AlphaLipoicAcid-Small-2016 (2).jpg

Radiance Platinum [CVS] Alpha Lipoic Acid

5401_small_Solgar-AlphaLipoicAcid-Small-2016 (1).jpg

Solgar Alpha Lipoic Acid 200 mg (200 mg per vegetarian capsule

5402_small_SpringValley-AlphaLipoicAcid-Small-2016 (1).jpg

Spring Valley [Walmart] Alpha Lipoic Acid

Sundown Naturals Alpha Lipoic Acid

5757_small_Twinlab-AlphaLipoicAcid-Small-2017 (1).jpg

TwinLab Alpha Lipoic Acid 100 mg per capsule

5403_small_Vitacost-AlphaLipoicAcid-Small-2016 (1).jpg

Vitacost Alpha Lipoic Acid

5404_small_VitaminWorld-AlphaLipoicAcid-Bottle-Small-2016 (1).jpg

Vitamin World Alpha Lipoic Acid 200 mg

5405_small_VitaminWorld-AlphaLipoicAcid-Small-2016 (2).jpg

Vitamin World Extra Strength Alpha Lipoic Acid

5406_small_VitaminWorld-AlphaLipoicAcid-TripleStrength-Small-2016 (2).jpg

Vitamin World Triple Strength Alpha Lipoic Acid

Make sure the alpha-lipoic acid supplement you take passed our quality review and is right for you!
Isn't your health worth it?

See the Review Now

Join now at www.consumerlab.com/join/

Summary

  • What is alpha-lipoic acid? Alpha-lipoic acid (or lipoic acid) assists in converting glucose into energy (See What It Is). A healthy body naturally produces enough alpha-lipoic acid but supplementation may help in certain situations.
  • What does alpha-lipoic acid do? Alpha-lipoic acid supplements may improve insulin sensitivity and blood sugar control, as well as reduce symptoms of peripheral neuropathy in people with type 2 diabetes. It may also increase weight and fat loss when combined with a low-calorie diet (See What It Does).
  • Which form of alpha-lipoic acid is best? Supplements contain synthetic versions of the naturally occurring form of alpha-lipoic acid (the R-isomer) or, more commonly, a mixture the R- and S-isomer forms. The R-isomer is the more active of the two isomers, however, only mixed forms have been studied for efficacy and side-effects in clinical trials and are generally much less expensive than R-isomer-only products. (See What to Consider When Buying).
  • How much alpha-lipoic acid should I take? The typical dose for treating diabetes, peripheral neuropathy associated with diabetes, and cardiac autonomic neuropathy is 200 to 400, taken 3 times daily (for a total daily dose ranging from 600 mg to 1,200 mg). For weight loss, 100 mg alpha-lipoic acid (taken three times per day with meals), along with a reduced-calorie diet, has shown to be beneficial. For use as a general antioxidant, a lower dose (20 to 50 mg daily) is commonly recommended (although there is no evidence this offers any health benefit). You may be able to halve the dose when using the R-isomer-only form (See What to Consider When Using).
  • Best choice for alpha-lipoic acid? Many products passed our tests of quality (See What CL Found). Among Approved products, ConsumerLab.com identified several which represented its Top Picks.
  • Safety and side effects of alpha-lipoic acid: Side effects such as skin rash and nausea have been reported. Alpha lipoic acid may also contribute to acid reflux, as it is an acid. Because alpha-lipoic acid may help control blood sugar in diabetics, adjustments may be needed to anti-diabetic medication when using alpha-lipoic acid. Alpha-lipoic acid may interfere with thyroid function, medication and diagnostic tests (See Concerns and Cautions).
You must be a ConsumerLab.com member to get the full test results along with ConsumerLab.com's recommendations and quality ratings. You'll get results for 19 alpha-lipoic acid supplements -- 10 selected by ConsumerLab.com and nine which passed testing in our voluntary Quality Certification Program, as well as information about three supplements similar to one that passed testing. 

In this comprehensive review, you'll discover: 
  • The best quality alpha-lipoic acid supplements and which passed or failed testing
  • Which alpha-lipoic acid supplements are the best value and are CL's Top Picks  
  • What alpha-lipoic acid can and cannot do for your health
  • How R-alpha-lipoic acid differs from mixed isomer alpha-lipoic acid
  • The dose of alpha-lipoic acid for specific uses   
  • Cautions when using alpha-lipoic acid, including side-effects, drug interactions, and interference with thyroid function, treatment, and tests (such as T3 and TSH)  

Join to unlock the full report and get full access to over 1,300 reviews

See the Review Now

Join now at www.consumerlab.com/join/