Initially Posted: 12/03/2016 | Last Updated: 07/28/2020
Alpha-Lipoic Acid Supplements Reviewed by

Alpha-lipoic acid supplements compared in this review

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Vitacost Alpha Lipoic Acid

Puritan's Pride Alpha Lipoic Acid 300 mg

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NOW Alpha Lipoic Acid

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Nature's Sunshine Alpha Lipoic Acid

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Jarrow Formulas Alpha Lipoic Sustain 300 with Biotin

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alpha betic Alpha Lipoic Acid

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Bronson Laboratories Alpha Lipoic Acid

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Country Life R-Lipoic Acid

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GNC Alpha Lipoic Acid 600 mg

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Natrol Alpha Lipoic Acid 600 mg

Nature's Bounty Alpha Lipoic Acid

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Olympian Labs Incorporated Alpha Lipoic Acid Naturopathic 400 mg

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Ortho Molecular Products Lipoic Acid

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Pure Encapsulations Metabolic Xtra

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Radiance Platinum [CVS] Alpha Lipoic Acid

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Solgar Alpha Lipoic Acid 200 mg (200 mg per vegetarian capsule

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Spring Valley [Walmart] Alpha Lipoic Acid

Sundown Naturals Alpha Lipoic Acid

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TwinLab Alpha Lipoic Acid 100 mg per capsule

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Vitamin World Alpha Lipoic Acid 200 mg

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Vitamin World Extra Strength Alpha Lipoic Acid

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Vitamin World Triple Strength Alpha Lipoic Acid

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Alpha-lipoic acid (also called lipoic acid) is an antioxidant that assists the body in the conversion of glucose to energy. Clinical evidence suggests it may improve insulin sensitivity and blood sugar control in people with type 2 diabetes, reduce symptoms of diabetic peripheral neuropathy, and enhance weight loss when dieting. However, it can be difficult to know which form of alpha-lipoic acid (R-isomer or "mixed" isomer) best suits your needs — and your budget!

Our tests identified many high-quality alpha-lipoic acid products — containing their claimed amounts of alpha-lipoic acid. If they contained additional ingredients, such as herbs, we also tested for potential contamination with the toxic heavy metals lead, cadmium and arsenic. 

Among the products which passed our tests and were CL Approved, the cost to get 100 mg of alpha-lipoic acid ranged from just 3 cents to 41 cents. You can easily save a lot of money by shopping wisely! 

Some of the more expensive products were made with R-isomer-only alpha lipoic acid, which has both pros and cons. 

You must be a member to get the full test results along with's recommendations and quality ratings. You'll get results for 19 alpha-lipoic acid supplements -- 10 selected by and nine which passed testing in our voluntary Quality Certification Program, as well as information about three supplements similar to one that passed testing. 

In this comprehensive review, you'll discover: 
  • The best quality alpha-lipoic acid supplements and which passed or failed testing
  • Which alpha-lipoic acid supplements are the best value and are CL's Top Picks  
  • What alpha-lipoic acid can and cannot do for your health
  • How R-alpha-lipoic acid differs from mixed isomer alpha-lipoic acid
  • The dose of alpha-lipoic acid for specific uses   
  • Cautions when using alpha-lipoic acid, including side-effects, drug interactions, and interference with thyroid function, treatment, and tests (such as T3 and TSH)  

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