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Several supplements have been shown to be helpful for nerve pain caused by conditions such as sciatica or diabetic neuropathy. These include fish oil, curcumin, alpha-lipoic acid (ALA) and GLA, vitamin B12, and benfotiamine. Sign in and read the full answer for details and dosage >>

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May 30, 2021

I take B-Complex and 2 doses of 300 mg of Alpha Lipoic Acid for sciatic nerve pain. It does help quite a bit. 600 mg per day of ALA was the effective dose for me. However, I found taking a 600mg ALA capsule caused me to have an irregular heartbeat. So I quit taking it. I tried 300 mg once per day and had no irregular heartbeat issue and after taking it for a month, I added a second pill spaced 12 hrs apart and have had no issue since. I will say at least for me, only 300 mg per day was not effective, but I would say start with that and if it works stay with the lower dose. Always best to stick with the lowest effective dose, IMHO.

May 12, 2021

Here is a product that really works on nerve pain. It is similar to a TENS unit but much more sophisticated. You can contact the company to find doctors in your area that have these. I am in no way invested in, or connected to this company, but I have been treated with it.
May 12, 2021

We checked with the FDA, and this product (or a similar version) appears to have been cleared to be marketed in the U.S. (

April 9, 2020

I had great success with alpha lipoic acid until it aggravated terribly my esophagus due to reflux. Is there any type of ALA I can safely take? If not, what is the next best option? I have inflammatory demyelinating peripheral neuropathy. Pain is not my problem. I have weakness. When I was taking ALA I felt normal for the first time in 15 years.
April 30, 2020

Yes, alpha lipoic acid is, after all, an acid and it can contribute to acid reflux, as discussed in the "Concerns and Cautions" section of our Alpha Lipoic Acid Supplements Review at An enteric coated or timed release product may help.

November 19, 2019

What about Ortho-bionomy? Has anyone tried this? Usually done by someone who specializes in Massage Therapy.

November 16, 2016

I have sciatic nerve pain due to a back injury that has become fairly regular even after having had back surgery. Also had numbness in my foot. I tried taking alpha lipoic acid 600 mg once daily and it totally took care of the issue. It only took a couple of doses to get relief. However, after about a month or so of taking it I developed an irregular heartbeat. I quit taking it, but it took another month or so for that arythmia to go away. I've not taken it since. The nerve pain returns sporadically, but the numbness in my foot has not returned. So, just wanted to say it does work, but beware of that side effect. Perhaps starting off with a smaller dose would have been better.

September 6, 2015

I have a disc problem with resulting sciatic pain in my legs. Especially bad at night interrupting my sleep. I read an article on the internet that benfotiamine might be helpful. I started with 300 mg. daily. It took about 3 weeks to kick in and the pain was about 90% gone, but three weeks later it returned, so I increased the dosage to 600 mg. daily, and now I can say it is anywhere from 95 - 100% gone.
Also have started exercises to strengthen the back muscles hopefully to eliminate the nerve pain to start with.

November 15, 2015

You might want to try to correct the problem from a different angle. I have great success for problems with SI joint pain and knee and the ball of my foot. I used a therapy called Egoscue. It is therapy that corrects posture which when corrected, eliminates pain in the body. You can go to a clinic and buy the book called Pain Free by Pete Egoscue. This is a different approach from physical therapy or chiropractic care.

November 16, 2015

Great to hear that you have less pain. I would also recommend SOT chiropractic, which is very gentle approach that corrects pressure in the low back by balancing the pelvis with wedges called "blocks." You can find an SOT doctor by going to I would not recommend a chiropractor who does twisting movements of the low back, though, because the problem might involve a weak or bulging disc and forceful adjustments can cause further damage.

February 12, 2019

Thanks for the tip. So in your experience 600mg/day works better than 300mg/day.

Pilates classes may help you to remember to use your deep abdominal muscles.

September 3, 2021

I started a Keto diet I saw watching Dr. Berg, I lost 25 lb.’s to 150 lb. I am 68 and many of my aches and pains went away, blood pressure down too! I do 18-2 includes intermittent fasting, 18 hrs and meals at 12PM and 6PM, 25-50 carbs a day, I had to increase to 75 carbs because I kept losing 1 lb. a day. I take supplements as well and electrolytes.

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