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L-Citrulline Review 2023
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Does L-citrulline work?

  • What is L-citrulline?

    L-citrulline (or citrulline) is a non-essential amino acid that the body can convert to L-arginine, which is necessary for the body's production of nitric oxide, a compound that relaxes blood vessels and allows more blood to flow through arteries. (See What It Is)
  • Despite much hype, clinical studies of L-citrulline for exercise performance and cardiovascular uses have shown only modest to no benefit. Only one small study suggests that L-citrulline benefits men with mild erectile dysfunction. Studies on benefits for brain function, such as after stroke, have been limited to those in mice. (See What It Does)
  • Which is the best L-citrulline supplement?

    Among products shown to be accurately labeled in our tests (one product was not) and that passed our tests for heavy metals such as lead (see What CL Found), we selected Top Picks for L-citrulline as a powder and as a pill, both of which provide L-citrulline at relatively low cost.
  • Is L-citrulline malate a better form?

    Both L-citrulline and L-citrulline malate can raise levels of L-citrulline in the body, but there are several reasons why we prefer the L-citrulline form. (See What to Consider When Buying)
  • L-citrulline safety and side effects:

    L-citrulline supplementation appears to be generally safe and well tolerated in healthy individuals, although occasionally, gastrointestinal upset and heartburn have been reported, and it should be used with caution by people on medication that lowers blood pressure. (See Concerns and Cautions)

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L-citrulline supplements compared in this review

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Amazing Formulas L-Citrulline

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Best Naturals L-Citrulline

View Larger Image BulkSupplements.com_L-Citrulline-L-Citrulline-2023-small.png L-Citrulline

View Larger Image Doctors_Best_L-Citrulline_Powder-L-Citrulline-2023-small.png

Doctor's Best L-Citrulline Powder

View Larger Image Double_Wood_Supplements_L-Citrulline-L-Citrulline-2023-small.png

Double Wood Supplements L-Citrulline

View Larger Image GNC_Pro_Performance_Citrulline_Complex-L-Citrulline-2023-small.png

GNC Pro Performance Citrulline Complex

View Larger Image Healthy_Origins_L-Citrulline-L-Citrulline-2024-small.png

Healthy Origins L-Citrulline

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Now Sports L-Citrulline 1,200 mg

View Larger Image Nutricost_L-Citrulline_Malate_2-1-Unflavored-L-Citrulline-2023-small.png

Nutricost L-Citrulline Malate 2:1 - Unflavored

View Larger Image True_Nutrition_Citrulline_Malate_Powder-L-Citrulline-2023-small.png

True Nutrition Citrulline Malate Powder

You must be a member to get the full test results along with's recommendations and quality ratings. You will get results for eight L-citrulline supplements selected for testing by as well as for two others that passed the same testing in CL's voluntary Quality Certification Program. In this comprehensive review of L-citrulline supplements you'll learn:
  • Which L-citrulline supplements passed testing, and which failed
  • ConsumerLab's Top Picks among L-citrulline supplements, including tablets, capsules, and powders
  • Which high-quality L-citrulline supplements are also lowest cost
  • What L-citrulline can and cannot do for your health, including information about exercise endurance and recovering, lowering blood pressure improving cognition, and more
  • The potential advantages and differences of forms of L-citrulline, including L-citrulline and citrulline malate C
  • What to look for on labels when choosing an L-citrulline supplement
  • The dosage of L-citrulline used for different purposes
  • The potential side-effects and drug interactions with L-citrulline

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Additional Information
Tested through CL's Quality Certification Program prior to, or after initial posting of this Product Review.