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CoQ10 and Ubiquinol Supplements

CoQ10 2024

Trying to find the best CoQ10 or ubiquinol supplement? ConsumerLab tested 20 CoQ10 and ubiquinol products. Find out which ones passed or failed our review, how they differ, and which we consider Top Picks. Also learn what CoQ10 and ubiquinol can and cannot do, and information about dosage and safety.

CoQ10 and Ubiquinol Supplements Review

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CL Answer

What is the difference between CoQ10 and ubiquinol?

Understand the difference between CoQ10 (ubiquinone) and the active form, ubiquinol, and how they are best absorbed. ConsumerLab explains.

The Difference Between CoQ10 and Ubiquinol -- CoQ10 Supplement

CL Answer

When taking a water-soluble version of CoQ10, do I still need to take it with food?

Find out how best to take CoQ10 supplements, with water or food.

water-soluble version of CoQ10

CL Answer

What are CoQ10 side effects?

CoQ10 side effects, such as nausea, headache, and insomnia, and how you can reduce the occurrence of CoQ10 side effects. ConsumerLab.com's answer explains.

CoQ10 2024

CL Answer

Can CoQ10 or ubiquinol be ruined by heat? I recently purchased several bottles of Qunol Plus from Costco.com and they arrived hot. The soft gels are not melted, but I am concerned.

Find out whether your CoQ10 or ubiquinol supplement can be destroyed by heat during shipping and at what temperature CoQ10 softgels can melt. ConsumerLab.com's answer explains.

Box of Vitamins and Supplements

CL Answer

How do I choose the best CoQ10 supplement?

Looking to choose the best CoQ10 brand supplement? Understand which CoQ10 you are buying, differences in dose, absorption, quality and more. ConsumerLab explores this topic.

Pill Bottle Q10 Spelled Out with Supplements

CL Answer

Do CoQ10 levels really decrease with age?

Find out if CoQ10 levels decrease with age in the blood, brain & heart and at what age these decreases begin.

News Release

April 11, 2024

Best CoQ10 & Ubiquinol Supplements According to ConsumerLab Tests

White Plains, NY, April 11, 2024 —  CoQ10 and its active form, ubiquinol, are among the most popular supplements, taken by 42.2% of supplement users, often taken by people on cholesterol-lowering statin medication and for a variety of other conditions.

CL Answer

Which supplements have been shown to be helpful for autism?

Find out which supplements may help reduce symptoms of autism, including multivitamins, probiotics, and melatonin.

Bottle and Pills Spread Out on Blue Background

News Release

February 26, 2024

Latest ConsumerLab Survey Shows Growth in Popularity of Magnesium and Several Smaller Supplements

White Plains, New York, February 26, 2024 — A recent survey of more than 10,000 people who regularly use dietary supplements shows that supplements that experienced the greatest absolute growth in popularity during 2023 were pregnenolone (+7.5 percentage points), magnesium (+4.8 pts), berberine (+4.

News Release

February 24, 2023

Probiotics Rise in Popularity as Vitamin C, Melatonin, and Others Dip in Latest ConsumerLab Survey of Supplement Users

White Plains, New York, February 25, 2023 —A recent survey of 8,600 people who regularly use dietary supplements shows that probiotics (+3.04 percentage points), quercetin (+2.3 pts), and vitamin K (+1.

CL Answer

Could my CoQ10 supplement be making me nauseous?

Find out if CoQ10 can cause gastrointestinal symptoms like nausea, diarrhea & upset stomach.

Young Man in White Tee Holding Stomach with Hand Over Mouth

CL Answer

Could my CoQ10 supplement be causing my insomnia?

Learn more about the impact on sleep that supplements such as CoQ10, St. John's wort, and DHEA may have. Insomnia may be caused by certain supplements.

Woman with insomnia awake in bed and having trouble sleeping

News Release

February 24, 2022

Consumers Returned to Pre-Pandemic Supplement Usage in 2021, ConsumerLab Survey Reveals

White Plains, New York, February 24, 2022 —A survey of 8,049 people who use dietary supplements shows many supplements that declined in use in 2020 began bouncing back in 2021, such as magnesium (+2.4 percentage points), and CoQ10 (+2.7 pts).

Clinical Update

6/26/2018

Ubiquinol for Blood Sugar Control?

Does giving ubiquinol (the active form of CoQ10) to people with type 2 diabetes help with blood sugar control? Find out in the What It Does section of the CoQ10 and Ubiquinol Supplements Review. (Also see our Top Picks among CoQ10 and ubiquinol supplements.)

Clinical Update

8/04/2020

Ubiquinol & Heart Surgery

Ubiquinol (the active form of CoQ10) can have a beneficial effect on ailing hearts, but can taking it protect the heart around the time of aortic valve replacement? Find out what a recent study showed in the What It Does section of the CoQ10 and Ubiquinol Supplements Review. Also see our Top Picks for Ubiquinol and CoQ10.

Clinical Update

6/02/2020

Ubiquinol for Fatigue?

Does taking ubiquinol (the active form of CoQ10) help men and women who are experiencing fatigue in daily life? Find out what a recent study showed in the What It Does section of the CoQ10 and Ubiquinol Supplements Review. Also see our Top Picks for CoQ10 and ubiquinol.

Clinical Update

1/31/2021

Ubiquinol (CoQ10) for Cognitive Function?

Does taking ubiquinol, the active form of CoQ10, improve cognition in people with mild cognitive impairment? See what a new study found in the What It Does section of our CoQ10 and Ubiquinol Supplements Review. Also see our Top Picks for CoQ10 and ubiquinol.

News Release

September 11, 2021

Best CoQ10 and Ubiquinol Supplements Identified in Testing by ConsumerLab

White Plains, New York, September 11, 2021 — CoQ10 and ubiquinol, the active form of CoQ10, are often taken to offset a decline in natural levels that occurs with the use of statin (cholesterol-lowering) medication, and are also promoted for increasing energy and anti-aging effects.

Product Review

PQQ (Pyrroloquinoline Quinone) Supplements Review

Learn What PQQ Does and Which PQQ Supplements are Best

CL Answer

I recently bought a CoQ10 supplement on Amazon. The manufacture date was hidden under a sticker, but was 13 months ago. No "Best By" date is listed. Is this product still good to use?

Find out how long your CoQ10 supplement should last, if your CoQ10 is expired, and how long it is good to use. ConsumerLab.com's answer explains.

Is My CoQ10 Expired? -- CoQ10 capsules in hand

CL Answer

Can taking CoQ10 affect my thyroid levels or interact with my thyroid medication?

Learn more about CoQ10 and thyroid medications along with natural thyroid function. ConsumerLab.com's answer explains.

Elderly Woman Checking Thyroid Gland

CL Answer

Is MitoQ a better form of CoQ10?

MitoQ information, including how it is absorbed in the body and how it compares to CoQ10.

Is MitoQ a better CoQ10? -- bottle of MitoQ

CL Answer

Is it safe to take CoQ10 while taking blood thinners like warfarin or Plavix (clopidogrel)?

Learn more about the possible counteractive effects of CoQ10 and blood thinners, including safety.

CoQ10

CL Answer

Is it safe to chew softgel supplements instead of swallowing them? Does this affect absorption of the ingredients?

Find out if it is safe to chew softgel supplements, instead of swallowing them, and if this affects absorption of the ingredients.

Chewing Softgels

CL Answer

Could taking vitamin C (500 mg), CoQ10, grape seed extract, fish oil, vitamin D3/calcium/magnesium/zinc interfere with taking beta-sitosterol with dinner?

Learn about drug interactions & proper dosages for supplements such as CoQ10, vitamin D & C, fish oil, magnesium, zinc and grape seed extract.

Doctor Holding Handful of Fish Oil

CL Answer

How much should I expect to pay for supplements? Are higher-priced supplements any better than low-priced brands?

Learn about the cost of supplements. Info including the best pricing on fish oil, CoQ10, vitamins C & D, magnesium, and calcium.

Cost and Quality of Dietary Supplements -- supplement bottles on store shelves

Clinical Update

7/10/2018

CoQ10 for Migraine

CoQ10 and its active form, ubiquinol, have been studied in several clinical trials to treat migraine headache. Find out what the research is showing in the Migraine section of the CoQ10 and Ubiquinol Supplements Review. (Also see our Top Picks among CoQ10 and ubiquinol supplements.)

Clinical Update

10/16/2018

CoQ10 vs. Ubiquinol

Which form of CoQ10 raises total blood levels of CoQ10 more? Find out in the CoQ10 and Ubiquinol Supplements Review. (Also see our Top Picks for CoQ10 and ubiquinol supplements.)

Clinical Update

11/30/2021

CoQ10 and Heart Failure

Can supplementing with ubiquinol, the active form of CoQ10, improve heart function in people with heart failure? See what a new study found in the What It Does section of our CoQ10 and Ubiquinol Supplements Review. Also see our Top Picks among CoQ10 and ubiquinol supplements.

Clinical Update

4/09/2024

CoQ10 Deficiency?

Due to genetics, are some people more likely to need CoQ10 or ubiquinol? Find out in our CoQ10 and Ubiquinol Supplements Review, which includes our Top Picks for CoQ10 and ubiquinol.

Clinical Update

6/01/2022

Ubiquinol for Heart Failure

Can supplementing with ubiquinol help people with diastolic heart failure? Find out what a recent study showed. Also see if CoQ10 helps with congestive heart failure in the Cardiovascular Health section of our CoQ10 and Ubiquinol Supplements Review.

CL Answer

Do any supplements help with gum disease or periodontitis?

Supplements for healthy gums may help with gum disease or periodontitis. Learn more about omega fatty acids, lycopene, and probiotics.

Smiling Woman Taking White Supplement with Glass of Water

CL Answer

Are supplements which claim increased absorption or improved bioavailability telling the truth? Is it worth paying more for these? Are there concerns?

Learn more about bioavailability enhancers, including emulsifiers and enzyme inhibitors.

Enhancers in Supplements

News Release

February 26, 2021

COVID Changed Supplement Popularity in 2020, ConsumerLab Survey Reveals

White Plains, New York, February 26, 2021 — A survey of 9,647 people who use dietary supplements shows that the supplements which experienced the greatest growth in popularity in 2020 were those being promoted to prevent or treat infection with SARS-CoV-2, the coronavirus that causes COVID-19.

Clinical Update

10/30/2018

CoQ10 & Statin Muscle Symptoms

Can taking CoQ10 reduce muscle symptoms that can occur when taking cholesterol-lowering statin drugs? Find out in the recent update to the What It Does section of the CoQ10 & Ubiquinol Supplements Review. (Also see our Top Picks for CoQ10 and Ubiquinol.)

Clinical Update

11/06/2018

Can CoQ10 Boost Cholesterol-Lowering of Statins?

Can taking CoQ10 further lower cholesterol levels in people already taking a statin drug? See what a new study found in the What It Does section of the CoQ10 and Ubiquinol Supplements Review. (Also see our Top Picks for CoQ10 and ubiquinol supplements.)

Clinical Update

8/10/2019

CoQ10 for Fibromyalgia?

A recent study evaluated whether CoQ10 improved symptoms in patients with fibromyalgia when added to standard prescription treatment with pregabalin (Lyrica). See the results, and learn more about what CoQ10 can and cannot do in the What It Does section of the CoQ10 and Ubiquinol Supplements Review. Also see our Top Picks for CoQ10 and ubiquinol.

Clinical Update

3/21/2020

CoQ10 Bioavailability

CoQ10 is not well absorbed unless taken with fats or oils, such as with a meal. Bioavailability-enhanced formulations allow CoQ10 to be taken without a meal, but how good are they? We've added new information about one such formula and how it compares to taking regular CoQ10 in the Absorption and Bioavailability Enhancers section of the CoQ10 and Ubiquinol Supplements Review. Also see our Top Picks for CoQ10 and ubiquinol.

Clinical Update

11/26/2014

CoQ10 Reduces Statin-Related Muscle Pain

Taking a moderate dose of CoQ10 reduced statin-related muscle symptoms in 75% of patients in a recent study. More details, as well as our tests of CoQ10 and ubiquinol products, are found in the CoQ10 & Ubiquinol Supplements Review >> 

Clinical Update

6/06/2023

CoQ10 for Strength?

Does supplementing with the ubiquinol form of CoQ10 improve muscle strength in well-trained men? Find out what a recent study showed in the Strength and athletic performance section of our CoQ10 Supplements Review.

Also see our Top Picks for CoQ10 and ubiquinol.

Clinical Update

4/16/2024

MitoQ for Arteries?

Did taking MitoQ, a compound related to CoQ10, improve cardiovascular fitness in older men and women? See what a recent study found in the MitoQ section of our CoQ10 & Ubiquinol Supplements Review, which includes our Top Picks among CoQ10 and ubiquinol supplements.

Clinical Update

3/10/2020

Does CoQ10 Help With Statins?

Many studies have looked at whether or not CoQ10 helps people with statin-associated muscle pain. Read the latest in the What It Does section of the CoQ10 and Ubiquinol Supplements Review. Also see our Top Picks for CoQ10 and ubiquinol supplements.

CL Answer

Is there evidence that d-limonene can help fight cancer?

Find out if d-limonene can help fight cancer or help for GERD (gastroesophageal reflux disorder), including evidence from clinical studies.

Lemon with Peel Coming Off

CL Answer

Which supplements or foods can help lower cholesterol and keep my heart healthy? Are there any to avoid?

Information about heart health supplements & vitamins that help with cholesterol, including sterol esters, CoQ10, and vitamin D, and which may be bad for the heart, like calcium.

Clinical Update

6/02/2013

Does CoQ10 Help the Heart?

It can for people with congestive heart failure, says a new study. Find out more about CoQ10, plus get ratings for 48 supplements in the updated Coenzyme Q10 and Ubiquinol Supplements Review >>

Clinical Update

3/27/2014

CoQ10 Not Helpful in Parkinson Disease

A study among people with early Parkinson Disease found that high-dose CoQ10 was not effective in slowing progression of the disease. For details about the study, information about other uses of CoQ10, as well as our tests of supplements, see the updated CoQ10 and Ubiquinol Supplements Review >> 

Clinical Update

10/10/2014

CoQ10 Benefit Takes Time

A large study found that a daily dose of CoQ10 reduced the chances of hospitalization or death by almost 50% in people with moderate to severe heart failure -- but only after being taken for an extended period of time. Find out how much CoQ10 was taken and for how long, and get our quality ratings and comparisons of CoQ10 supplements, in the updated CoQ10 and Ubiquinol Supplements Review >>

Clinical Update

11/12/2014

CoQ10 Improves Symptoms in War Veterans

A new study found that a moderate dose of CoQ10 improved symptoms of Gulf War illness (such as word recall, fatigue, and irritability) in veterans. A larger dose did not show this effect. Details, as well as results of our product tests, are found in the CoQ10 & Ubiquinol Supplements Review >> 

Clinical Update

1/10/2017

CoQ10 for Fibromyalgia

CoQ10 reduced symptoms of anxiety and depression in people with fibromyalgia, according to a preliminary study. Get the details, including dosage, in the "What It Does" section of the CoQ10 and Ubiquinol Supplements Review >>

Clinical Update

10/31/2017

CoQ10 for Orthostatic Hypotension

CoQ10 may help reduce the fall in blood pressure that occurs in orthostatic hypotension (low blood pressure upon standing) according to a recent report. See the details in the "What It Does" section of the CoQ10 and Ubiquinol Supplements Review >> [Also see our Top Picks for CoQ10 supplements in the Review.]

Clinical Update

1/06/2018

Can CoQ10 Lower Cholesterol?

A recent study looked at whether CoQ10 can lower cholesterol in people with elevated levels. Find out what the study found and details about dosage in the "What it Does" section of the CoQ10 and Ubiquinol Supplements Review >> (Also see our Top Picks among products.)

Clinical Update

2/17/2018

CoQ10 for Nerve Pain

Taking CoQ10 along with standard medication may decrease trigeminal (facial) nerve pain more than medication alone, according to a new study. For details, including dosage, see the What It Does section of the CoQ10 and Ubiquinol Supplements Review. (Also see our Top Picks among products).

Clinical Update

8/25/2021

Supplement for Better Exercise Performance?

Can taking a modified form of CoQ10 known as mitoquinone improve exercise performance in middle-aged men? See what a recent study found in our CoQ10 and Ubiquinol Supplements Review, which also includes information about a potential concern with mitoquinone.

Clinical Update

8/23/2022

CoQ10 and Blood Sugar

Moderate doses of CoQ10 may lower blood sugar and improve insulin sensitivity in some people, but higher doses may not, according to a recent study. Get the details in the What It Does section of our CoQ10 and Ubiquinol Supplements Review.

Also see: Which supplements and foods can help lower or control blood sugar?

Clinical Update

9/02/2022

CoQ10 for Statin-Related Muscle Pain?

Can CoQ10 supplementation reduce muscle pain in people taking cholesterol-lowering statin medication? See what a recent study found in the What It Does section of our CoQ10 and Ubiquinol Supplements Review.

Also see: When taking a statin drug like Lipitor or Crestor, are there supplements I should avoid or take?

Clinical Update

4/15/2022

CoQ10 for Tinnitus?

Can CoQ10 supplementation reduce symptoms of tinnitus? Find out what research suggests in the What It Does section of our CoQ10 and Ubiquinol Supplements Review.

For information about other supplements for tinnitus, see our answer to the question: Do any supplements or lifestyle changes reduce the symptoms of tinnitus? Is it true that some supplements can cause tinnitus?

Clinical Update

4/29/2022

CoQ10 & Cholesterol

Did supplementing with CoQ10 improve HDL cholesterol levels or function among people with high cholesterol? Find out what a recent study showed, and also learn how CoQ10 affects LDL cholesterol, in the Cardiovascular Health section of our CoQ10 and Ubiquinol Supplements Review.

CL Answer

Do vitamins, minerals or other supplements lose effectiveness with exposure to high temperatures?

Are vitamins and supplements susceptible to heat? Find out if mail ordering during the summer is safe.

Heat's Effect on Supplements in the Mail -- Woman receiving a package

CL Answer

Do any supplements or foods help with migraine? Do any trigger migraine?

Find out if supplements such as magnesium, CoQ10, riboflavin, butterbur, feverfew and others help with migraine. Also learn about foods that may trigger migraine, including chocolate and watermelon.

Migraine

CL Answer

I take VitaPulse dietary supplements from the Princeton Nutrients. Once the bottle is open for a week or so, the contents begin to smell. Should I be concerned?

Find out if it is normal for VitaPulse with N-acetylcysteine (NAC) to have a sulfur-like odor.

News Release

July 31, 2019

ConsumerLab Tests Reveal Best CoQ10 and Ubiquinol Supplements

White Plains, New York, July 31, 2019 — CoQ10 is among the most popular supplements, commonly taken to offset a decline in natural levels of CoQ10 that can occur with the use of statin medications, decrease statin side effects, and increase energy.

News Release

December 21, 2016

Best CoQ10? ConsumerLab.com Tests Popular CoQ10 and Ubiquinol Supplements and Reveals Its Top Picks

White Plains, New York, December 21, 2016 — Although CoQ10 and ubiquinol are among the most popular supplements, wide variations in price, dosage, absorption and bioavailability can make choosing the right product a difficult task. To help, ConsumerLab.

CL Answer

Which supplements can help to lower blood pressure?

Supplements to lower blood pressure, including CoQ10, vitamin C, fish oil, and olive oil, are all explored to find out what works.

Supplements that can lower, or raise blood pressure -- blood pressure cuff and bottle of pills

CL Answer

When taking a statin drug like Lipitor or Crestor, are there supplements I should avoid or take?

Learn about the interactions between certain supplements and atorvastatin (Lipitor), rosuvastatin (Crestor), and other cholesterol-lowering statins.

Statin Interactions With Supplements -- close-up of statin medication box and tablets

Recalls & Warnings

November 21, 2022

6 Supplement Companies Warned by FDA for Making Cholesterol Claims

On May 4, 2022, the FDA issued warning letters to six supplement companies following review that found statements made on company websites and Walmart purchase pages suggesting the products could lower cholesterol to be drug claims, which are not permitted for dietary supplements.

CL Answer

Are antioxidant supplements good or bad for you?

Learn more about whether antioxidants like astaxanthin, beta-carotene, coenzyme Q10, curcumin, resveratrol, selenium, vitamin A, vitamin C and vitamin E are safe and if they help prevent chronic diseases.

Can Antioxidants Cause You to Die Sooner? -- antioxidant supplements and carrots

Recalls & Warnings

January 20, 2021

FDA Warns Seller of Vitamin D, Curcumin and CoQ10 Promoted for Treating COVID-19

On December 28, 2020, the FDA issued a warning letter to Smarter Nutrition, Inc. following a review of the company's website, which found statements made about the company's products Smarter Curcumin, Smarter Ubiquinol, and Smarter Vitamin D3 to be drug claims.

News Release

March 17, 2015

CoQ10 & Ubiquinol Supplements Vary in Quality, as Well as Dose, Absorption, and Price According to ConsumerLab.com

White Plains, New York, March 17, 2015 — Findings from a recent study by ConsumerLab.com highlights the difficulty consumers have in selecting a supplement containing the highly-popular anti-oxidant CoQ10 or its activated form, ubiquinol. ConsumerLab.

News Release

February 13, 2014

Calcium, Vitamin C, and Fish Oil Supplements Drop in Use, Probiotics Rise According to ConsumerLab.com Survey

White Plains, New York, February 13, 2014 — A recent survey of over 10,000 people who use dietary supplements shows that the use of calcium, vitamin C and fish oil supplements fell during 2013 while the use of probiotics increased.

Recalls & Warnings

February 18, 2020

Seller of CoQ10, Resveratrol and More Warned for Manufacturing Violations

On February 5, 2020, the FDA issued a warning letter to R-Garden LLC, which found the company's Vitamin O, Gamma-Zyme, L.

Recalls & Warnings

February 13, 2019

Supplements Promoted for Alzheimer's Disease and Dementia Sell "False Hope," Warns FDA

On February 11, 2019, the FDA warned consumers to beware supplements promoted to prevent or treat Alzheimer's disease or dementia.

News Release

March 05, 2013

CoQ10 & Ubiquinol Supplements Should Be Chosen Carefully, Cautions ConsumerLab.com -- Less Than 4% of Listed Ingredient Found in Widely-Sold Product

White Plains, New York — March 5, 2013 — A new report from ConsumerLab.com highlights the difficulty consumers have in selecting a supplement containing the anti-oxidant CoQ10 or its activated form, ubiquinol. ConsumerLab.

News Release

March 08, 2011

ConsumerLab.com reviews CoQ10 and ubiquinol supplements -- Tests show quality to be high, but large differences found in dosage, formulation, and cost

WHITE PLAINS, NEW YORK — MARCH 8, 2011 — A new report by ConsumerLab.com highlights the difficulty consumers may have in selecting a supplement containing the anti-oxidant CoQ10 or its activated form, ubiquinol. CoQ10 is among the most popular dietary supplements in the U.S.

News Release

January 13, 2009

ConsumerLab.com reports largest test of CoQ10 and ubiquinol supplements -- Most supplements provide claimed ingredient, but large variation in dosage and forms may confuse consumers. ConsumerLab.com provides guidance.

WHITE PLAINS, NEW YORK — JANUARY 13, 2009 — A report by ConsumerLab.com on supplements containing the anti-oxidant CoQ10 shows the difficulty for consumers in determining an appropriate dosage.

Recalls & Warnings

October 24, 2012

Warning Issued to Memory Supplement Maker For Unapproved Drug Ingredient, Drug Claims and Unreported Adverse Events

On October 16, 2012, the FDA issued a letter to dietary supplement manufacturer Quincy Bioscience Manufacturing Inc.

Recalls & Warnings

June 26, 2015

Seller of CoQ10, Anxiety Supplements and More Warned for Manufacturing Violations, Drug Claims

On June 6, 2015, the FDA issued a warning letter to Country Doctor Herbals, following a facility inspection which found the company's products, including  Herbal Flu Be-Gone, Herbal Multi-Bac, Herbal Nervine, Herbal Pain-A-Way, Herbal Pancreas, Herbal Parasite Cleanse, Herbal Perfect ...

Recalls & Warnings

September 13, 2013

Metagenics Warned For Misbranding of Medical Foods and Drug Claims

On August 13, 2013, the FDA issued a warning letter to Metagenics, Inc.