Powdered supplements that are mixed with liquid may be preferable for people who have undergone gastric bypass surgery, or have conditions that reduce the ability to digest foods. Normally, however, assuming that a pill is properly made to disintegrate in a short period of time in your stomach, it should not matter if you take a powder or a pill.
Nevertheless, be aware that ConsumerLab.com has found that about 5% of products sold as tablets don’t disintegrate as fast as they should, and some fail to disintegrate at all. In those situations, a powder would be preferable. You are unlikely to have any disintegration issues with regular capsules and softgels, although ConsumerLab.com has found that some enteric-coated and timed-release products release ingredients before they should. You can check the test results within our Product Reviews to see whether a tablet or enteric-coated or timed-release pill passed or failed our testing. You'll also see how powders fared because, absorption aside, some have failed our tests for other reasons.
If you do use a powdered supplement, be sure that when you mix it with a drink, you stir thoroughly and consume the full contents of the drink -- as some material may remain at the bottom of the cup. See our CL Answer to the question about moisture and clumping with some powders for tips about using and storing powdered supplements.