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Question: I have heard that caffeine can interfere with the benefits of creatine supplementation. Is that true?
Answer: It is true that some evidence suggests caffeine can diminish the effectiveness of creatine. However, this negative effect appears to depend on whether caffeine is taken on a short-term or long-term basis. For details and more about the use of creatine, see the "What to Consider When Using" section of the Review of Muscle Enhancers (Creatine and Branched-chain Amino Acids) -- which includes our tests and comparisons of products.