Do diamine oxidase (DAO) supplements for histamine intolerance really work?

Answer:

Histamine intolerance refers to a wide range of symptoms (such as itching, rash, migraine headache, gastrointestinal distress and difficulty breathing) that can be triggered by eating foods rich in histamine (fish, cheese, sausage, wine, and beer) or by taking certain drugs. There is evidence that, in some people, symptoms of histamine intolerance can be caused by low activity of the DAO enzyme, which helps to break down histamine in the body. Supplements containing DAO are promoted to help break down histamine to reduce symptoms.

Sign in to the full answer to find out what studies of DAO supplements have shown and and for details about dosage possible side effects. Also learn which supplements are similar to what has shown best results in clinical trials. Products covered include Food Sensitivity Relief with Diamine Oxidase (DA0) by Life Extension, Histamine Block by Seeking Health, Histamine Blocker by Bravado Labs, Histamine Digest by Omne Diem, Histamine Manager by Healthy Habits Living, Naturdao, Hist-Resist by Vinco, HistaEze by Designs for Health, and Natural D-Hist by Ortho Molecular Products.