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Answer:

Histamine intolerance refers to a wide range of symptoms (such as itching, rash, headache, gastrointestinal distress and difficulty breathing) that can be triggered in some people by eating foods rich in histamine (fish, cheese, sausage, wine, and beer) or by taking certain drugs. There is evidence that in some people, symptoms of histamine intolerance could be caused by low activity of the DAO enzyme, which helps to break down histamine in the body. Supplements containing DAO are promoted to help break down histamine to reduce symptoms.

Sign in to the full answer for more information including foods to avoid, studies evaluating DAO supplementation for symptoms of histamine intolerance including hives, gastrointestinal symptoms and migraines, DAO dosage, and which DAO supplements in the U.S. are similar to what has worked in clinical trials.

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