Answer:

There have been just a few case reports suggesting that glucosamine may raise LDL cholesterol levels (WHO Pharmaceuticals Newsletter 2005). However, most clinical studies have not found glucosamine supplementation (glucosamine sulfate or glucosamine chloride taken for 3 months to 3 years, at doses ranging from 1,200 mg to 1,500 mg daily) to be associated with increases in cholesterol (Østergaard, Ugeskr Laeger 2007; Palma Dos Reis, Open Rheumatol J 2011; Eggertsen, BMC Pharm & Tox 2012).

Although glucosamine is unlikely to raise cholesterol levels in most people and is generally considered safe, keep in mind that, in some people, it can cause an allergic reaction, increase eye pressure, and have an anti-coagulant effect. People who need to restrict their sodium intake should avoid forms of glucosamine that contain sodium chloride.

For more information about these effects, tips for using glucosamine and appropriate dosage, and ConsumerLab.com’s tests and reviews of many glucosamine supplements, see the Joint Health Supplements Review (Glucosamine, Chondroitin, Boswellia, and MSM)>>

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2 Comments

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William17488
January 23, 2019

I started taking glucosamine with chondriotin and MSM and a few months later I had my yearly physical. My LDL cholesterol, Triglyceride and total cholesterol were all about 20 points higher. I quit taking them and 3 months later had another blood test and all had dropped back down 7 to 14 points. On my next yearly physical they were all back to normal.
I remember reading about research in Sweden that showed that only a very small percentage of users were affected by glucosamine.

Richard16352
January 14, 2018

I have been taking glucosamine for 15 years, and at my age-73 annual physical my LDL was LESS than my HDL. I am not on any drugs (or supplements) targeting cholesterol. My family history is one of early death from stroke or heart attack.

Jonathan16969
July 25, 2018

i HAVE BEEN USING GLUCOSAMINE FOR 20 YEARS NOW AND HAVE EXTENSIVE BLOOD WORK EVERY 3 MONTHS DUE TO HORMONE THERAPY. MY CHOLESTEROL IS PERFECT EVERY TIME. HOWEVER, I EAT A VERY CLEAN DIET RICH IN VEGETABLES, FRUITS, LEAN PROTEIN AND STAY AWAY FROM PROCESSED FOODS.

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