uses JavaScript to provide the best possible experience for our content, but your browser has it disabled. Learn how to enable it here.



Heart disease remains the leading cause of death for both women and men in the U.S.  Some supplements may help keep your heart healthy, but others may potentially contribute to heart disease.

Supplements That May Help

There is strong evidence that sterol esters (like the phytosterol beta-sitosterol) and stanol esters, available in supplements and in some "heart healthy" margarines and spreads, can significantly lower LDL cholesterol. (There is also some evidence that taking curcumin may increase the cholesterol-lowering effects of phytosterols.) You can get more information about this, plus our tests and reviews of products in the Cholesterol-Lowering Supplements Review.

Garlic has been shown to reduce total cholesterol and triglycerides, and may slow the development of atherosclerosis. One brand of garlic supplement in particular has been shown to lower triglycerides more than others. You can get more information about these, including our tests and reviews of products in the Garlic Supplements Review.

Red yeast rice can significantly lower cholesterol, but products vary widely in their amounts of natural, active statin compounds.  You can get more information and our tests and comparisons of products in the Red Yeast Rice Supplements Review.

High-dose niacin has been shown to lower LDL cholesterol. However, it should not be taken with statin-containing supplements (red yeast rice), or with statin drugs, which could increase the risk of serious events like stroke. You can get more information about niacin, including our tests and reviews of products in the B Vitamin Supplements Review.

Some, but not all studies suggest that pantethine (which is not a B vitamin but is often included as an ingredient in B vitamin supplements) may help to lower LDL cholesterol.

CoQ10 has been shown to significantly reduce the risk of adverse cardiovascular events by 50% in people with moderate to severe heart failure, and may be helpful in reducing some of the side-effects of cholesterol-lowering statin drugs. You can get more information about CoQ10 (and ubiquinol, a related compound), including our tests and reviews of products, in the CoQ10 and Ubiquinol Supplements Review.

Vitamin D may lower the risk of cardiovascular disease in those with low blood levels of vitamin D but not be of benefit for people who do not have a vitamin D deficiency. You can get more information about vitamin D, including our tests and reviews of products in the Vitamin D Supplements Review.

Similarly, improving magnesium to adequate levels can slightly reduce blood pressure, and magnesium blood levels in the mid to high normal range have been associated with a lower risk of death from cardiovascular disease, as noted in the Magnesium Supplements Review.

Berberine may help to reduce blood pressure, triglycerides and total and LDL cholesterol (as well as blood sugar) in people with type 2 diabetes; however, be aware that it may interact with several cholesterol-lowering medications, potentially increasing blood levels (and the risk of side effects) of these drugs.

Some, but not all studies suggest that extracts of citrus bergamot (Citrus bergamia) fruit may help to lower cholesterol levels in people with high cholesterol. It has been proposed that certain flavonoids in bergamot, including neoeriocitrin, naringin and neohesperidin, may, like statin medications, act on an enzyme involved in cholesterol synthesis (HMG-CoA reductase), or may influence an enzyme that plays a role in the metabolism of energy in cells (AMP-activated protein kinase or AMPK), although this remains to be proven (Nauman, Integr Food Nutr Metab 2019). In several small clinical trials, bergamot extract taken in daily dosages ranging from 150 mg to 1,500 mg daily (most studies used between 500 mg and 1000 mg of extract), alone or along with statin medication for one to six months, was generally well-tolerated and decreased total cholesterol levels by about 12 % to 31% , "bad" LDL cholesterol by 7% to 40% and triglycerides by about 11% to 39% in people with high cholesterol, metabolic syndrome or coronary artery disease compared to baseline or a control group (Lamiquiz-Moneo, Crit Rev Food Sci Nutr 2020).

Although the exact composition of the extracts used was not always provided, one trial that found modest reductions in total and LDL cholesterol compared to baseline in adults with high cholesterol levels used a branded extract (Bergavit) at a daily dosage of 150 mg of flavonoids standardized to contain 16% neoeriocitrin, 47% neohesperidin, and 37% naringin (Toth, Front Pharmacol 2015). However, not all studies have found a benefit, and, due to the limited size of these trials and wide variations in formulations, more research is needed. Few side effects other than heartburn have been reported in clinical trials, although longer-term studies are needed. Due to a potential blood-sugar lowering effect of bergamot extract (Mollace, Fitoterapia 2011), caution should be used in people taking blood-sugar lowering medications. Also be aware that bergapten, a compound in bergamot, may block potassium from entering nerve cells. This could cause hyperexcitability of nerve cells, resulting in involuntary muscle contractions and cramps if bergamot is consumed in large quantities. This was reported in a 44-year-old man who consumed approximately 4 quarts of Early Grey tea daily (which is traditionally flavored with bergamot) for three weeks. His symptoms resolved after reducing consumption of the tea (Finsterer, Lancet 2002).

Artichoke leaf extract may modestly lower total and, possibly, LDL cholesterol levels in people with high cholesterol, according to small-short-term studies, although larger, long-term studies are needed to confirm this. It does not appear to improve HDL cholesterol or triglyceride levels. Sign in for details about the dosage of artichoke leaf extract that has shown benefit.

Supplements That May Not Help

Calcium -- Although getting sufficient calcium may decrease your risk of dying from cardiovascular disease, too much may be harmful. A study found that calcium (800 mg) given once daily to postmenopausal women with high cholesterol caused a significant increase in serum cholesterol (up by about 50 mg/dL) and an increase in the thickness of lining of the carotid artery - changes associated with heart disease. Only if you don't get enough calcium should you consider a supplement, and it generally recommended that calcium supplementation not exceed 500 mg per dose, or more than 900 mg per day. You can get more information about these supplements, including our tests and reviews of products, in the Calcium Supplements Review.

Fish Oil -- Despite the fact that omega-3 fatty acids that have been linked to some heart healthy effects, it seems that the benefits come from consumption of fish, and not supplements. Only if you don't eat fish might fish oil supplements provide some heart benefit. Also, because fish oil supplements can have a blood-thinning effect, they should be used with caution in people taking other blood-thinning supplements or medications. You can get more information about these supplements, including our tests and reviews of products, in the Fish/Marine Oil Supplements Review.

Multivitamins have not been found to reduce (nor increase) the risk of heart attack, stroke or death from cardiovascular disease. You can get more information about these supplements, including our tests and reviews of products, in the Multivitamin and Multimineral Supplements Review.

Policosanol -- Although there is some evidence from several studies from Cuba suggesting a cholesterol-lowering effect, other studies have failed to find this effect, as noted in our Cholesterol-Lowering Supplements Review.

Certain probiotics may modestly lower systolic and diastolic blood pressure, and "bad" LDL cholesterol — although they do not appear to increase "good" HDL cholesterol. There is mixed evidence as to whether probiotics reduce triglyceride levels. More information, plus our tests of popular products, is found in the Probiotic Supplements and Kefirs Review.

Diatomaceous earth -- This silica-rich powder (from fossilized remains of microorganisms or "diatoms") has been promoted to lower cholesterol, although there is only weak evidence to support this use. A single, preliminary study among 19 men and women (ages 35 to 67) with moderately high cholesterol found that 250 mg of diatomaceous earth taken three times daily for two months modestly decreased average blood levels of total cholesterol (from 285 mg/dL to 248 mg/dL) as well as "bad" LDL cholesterol and triglycerides, compared to baseline (Wachter, Eur J Med Res 1998). However, placebo-controlled trials are needed to prove a benefit. The side effects and long-term safety diatomaceous earth supplementation is unknown and inhalation can causing coughing and shortness of breath. Chronic exposure to large amounts of inhaled diatomaceous earth through industrial use has been linked with lung cancer. Topical exposure can cause skin dryness, irritation and rash (Akhoundi, J Insect Sci 2013).

Supplements That May Be Harmful

Vitamin E supplements, once touted for heart health, have not been found to provide a benefit for people with cardiovascular disease, and could actually be harmful for some heart disease patients, since they could reduce the effectiveness of cholesterol-lowering agents.

There is reason to believe that L-carnitine and lecithin could actually contribute to atherosclerosis in certain people, and it may be wise to avoid long-term supplementation with either one.

Unlike artichoke leaf extract, drinking artichoke juice does not appear to be beneficial and may actually worsen triglyceride levels.


Cocoa powders and dark chocolate rich in flavanols can improve vascular function and blood pressure, and even raise levels of HDL ("good") cholesterol. You can get more information about these, as well as our tests and reviews of products in the Cocoa Powders, Extracts, Nibs, Supplements, and Chocolates Review.

Replacing some saturated fat in the diet with olive oil may help lower risk factors for heart disease, such as high blood pressure and high cholesterol. You can get more information about extra virgin olive oil and see our Top Picks among products in the Extra Virgin Olive Oil Review.

Oats and oat-based cereals can be a good source of soluble fiber, which can help to lower cholesterol reduce the risk of heart disease. See our Oat Cereals Review for the clinical evidence, including how much you need to consume in order to significantly reduce cholesterol.

There mixed evidence for whether soy can lower cholesterol. Although the FDA currently allows companies to make the claim that "25 grams of soy protein daily, as part of a diet low in saturated fat and cholesterol, may reduce the risk of heart disease," the agency has proposed revoking this health claim due to inconsistent findings (a final decision has not yet been made). In addition, a specific protein peptide isolated from soy, called lunasin, is sometimes promoted to lower cholesterol, but it was not shown to be beneficial in a clinical trial.

Eating walnuts every day may help lower "bad" cholesterol in older people, although it doesn't seem to improve "good" cholesterol or triglyceride levels. Sign in for details about the amount of walnuts eaten and whether any specific diet had to be followed.

Join today to unlock all member benefits including full access to all CL Answers and over 1,300 reviews.

Join Now

Join now at


Join the conversation

September 8, 2021

I was impressed with the data until I learned the project was funded by the walnut
I'm always suspicious when there's no corroborating studies by an impartial entity.

August 1, 2021

We've tried citrus bergamot and other supplements to lower cholesterol. So far, the only thing that has caused our cholesterol to go down by about 20 points is intermittent fasting. We eat two meals in an 8 hour period and that's it.

Dennis 22789
June 22, 2021

Can Bergamot be helpful in lowering LDL?
August 3, 2021

Hi Dennis, we've added information about bergamot to the answer above.

May 1, 2021

I started taking fish oil supplements and increased the amount of fish in my diet a couple of years ago, as part of a regimen to help lower my cholesterol, as I wish to avoid taking statins. I stopped the fish oil when I discovered it was causing occasional nosebleeds, sometimes heavy nosebleeds, and my research confirmed that this experience is common, especially in older women (I am 68). The nosebleeds have stopped now. I just wanted to share this, as I keep seeing fish oil recommendations for lowering cholesterol. Be careful!

February 11, 2020

Over years I tried various supplements, but the best results yet I got with
Citrus Bergamot extract- in my annual checkup I saw reduction of total cholesterol from 270 to 225, improved the ratio, and for the first time lowered triglyceride levels.
February 11, 2020

Hi Lazar - Thank you for sharing your experience.

April 24, 2021

I am unable to take Statins and therefor have tried various supplements to lower my cholesterol. I, also, tried Bergamot and was totally surprised and happy that it lowered my cholesterol from 270 to 219.

May 12, 2021

Hi Patricia and Lazar. Could you please share how long you were taking the Bergamot supplement for to see the desired effect? Bergamot, after 6 weeks of use, has not dropped my mother's LDL whatsoever.

December 4, 2019

About 10 years ago, I successfully lowered my cholesterol with high dose Niacin. For the next 8 years, my numbers were excellent. Two years ago, my cardiologist said that studies had shown that lowering cholesterol with Niacin has no effect on longevity. He told me to stop the Niacin, and go on a statin. Although the statin lowered my cholesterol in comparison to not taking anything, it did not lower it nearly as well as Niacin. I did not see anything about this in your information on Niacin. I would certainly prefer to take Niacin than Lipitor. What is the truth?
December 4, 2019

High-dose niacin is typically used if statins fail, as discussed in the Niacin section of the B Vitamins Review at There are risks with high-dose niacin, as discussed, although there are also risks with statins.

May 29, 2021

I’m a lipidologist. Your cardiologist was correct

December 1, 2019

What about citrus bergamot or pycnogenol for lowering cholesterol? There are several studies that support this claim. I just started taking citrus bergamot so I won't know for several months whether it works or not. I took pycnogenol but it caused aphthous stomatitis (one of the side effects) according to published research.

Cappello, A., Dolce, V., Iacopetta, D., Martello, M., Fiorillo, M., Curcio, R., … Dhanyalayam, D. (2016). Bergamot (Citrus bergamia Risso) Flavonoids and Their Potential Benefits in Human Hyperlipidemia and Atherosclerosis: an Overview. Mini-Reviews in Medicinal Chemistry, 16(8), 619–629. doi: 10.2174/1389557515666150709110222

April 9, 2019

I had read that citrus bergamot can lower cholesterol. So I searched and found clinical tests that used the brand Jarrow Citrus Bergamot. I had a total cholesterol of 258. It said to give the supplement a month and get my cholesterol rechecked. So I ordered 2 bottles for $45, which lasts 2 months. I re-took my cholesterol and my cholesterol was 200. I changed nothing else. A drop of 58 points in 30 days equals, I am staying on citrus bergamot.
April 11, 2019

Hi Dean - Thank you for sharing your experience with this.

December 1, 2019

What was your daily dosage?

December 1, 2019

My husband and I both took Citrus Bergamot for over a year with blood tests taken a year apart. There was absolutely no change in cholesterol numbers for either one of us. Needless to say, we discontinued this supplement.

December 25, 2019

What brand did you take?

March 24, 2018

I've done multiple lipids tests with fish oil and krill oil. The most extreme was 5 grams of Kirkland fish oil a day for three months. I've tried various other strict regimens of fish and krill oil, but not in that high of dose. The 5G fish oil test actually left me with higher triglycerides, up ~10%-20%, but not conclusively. In the end, none provided any noticeable benefit to my LDL, HDL, and especially my triglycerides (I have hypertriglyceridemia). It's good to see that acknowledged in your post here.

February 8, 2018

I was very surprised to read the following in the above article:

"There is strong evidence that sterol esters (like the phytosterol beta-sitosterol) and stanol esters, available in supplements and in some "heart healthy" margarines and spreads, can significantly lower LDL cholesterol."

Really???!!!. Do you recommend margarine and spread as something healthy and especially good for reducing risk of heart disease? What about the trans fats that margarine and spreads are so famous about? I feel like I am in the '60 again when butter was evil and margarine was godsend!
February 8, 2018

Hi Gabriel - The "margarines" referred to are not the old "stick margarines" with trans fats, but those made with polyunsaturated fats and no trans fats.

February 7, 2018

Pantethine can help lower cholesterol.
small bad particles should be evaluated with cholesterol.
February 13, 2018

Thank you for your comment Richard. We've added information about pantethine to the answer above.

February 1, 2017

What about Acetyl L-Carnitine? Does it have the same potential problems re atherosclerosis??
February 1, 2017

Hi Jeanne - Please see the "Concerns and Cautions" section of the Acetyl-l-carnitine (

July 17, 2016

What about vitamin K2?
There are many observational studies showing that K2 directs calcium away from arteries and into bones.
What do you think?
July 18, 2016

Hi Kenneth - Please see the "What It Does" section of the vitamin K review for more about vitamin K and coronary artery calcification:

June 19, 2016

I use flaxseed oil caps rather than fish oil for my omega-3. How does that fit in for "heart healthy"?
June 20, 2016

Hi Linda - Please see the "What It Does" section of the Flaxseed Oil Review ( for more about cardiovascular effects. You may also find this CL Answer helpful: Is it better to take fish oil, flaxseed oil -- or both? (

September 22, 2014

Regarding the statement that fish oil can have a blood-thinning effect, I think this should be researched because I have read that they do not thin the blood. Fish oil 'conditions' the blood so that the platelets are slippery and do not stick together. For many people taking blood thinners, with monitoring, their medication can safely be reduced.
Another benefit of good fish oil is it does not have mercury.

September 21, 2014

One of the most beneficial dietary supplement for cardiovascular health was left out of your list. Among its many benefits such as anti-inflammation and blood clotting, RESVERATROL provides blood thinning properties, and softens the arteries walls. Both benefits may prevent heart-attacks and strokes.
October 20, 2014

Hi Doron - The Resveratrol Review does mention potential cardiovascular effects of resveratrol while pointing out that, to date, clinical studies have not established a clear benefit in this regard - and even some concerns. You can read more about this in the What It Does section ( and Concerns and Cautions section ( of the report.

August 12, 2014

Recent Cacoa (as pure as possible eg. 85% cacao) studies show improved circulation and imply improved cardio vascular function. Should be considered for further review to include here.
August 12, 2014

Great point, Greg. Per your suggestion, we added a link to the Cocoa Review above, which covers that research -- as well as our product tests.

Join today to unlock all member benefits including full access to CL Answers

Join Now

Join now at