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Red Yeast Rice Supplements Reviewed by


Red yeast rice is effective because it naturally contains cholesterol-lowering "statin" compounds, such as lovastatin. However, studies in which statin drugs have been given with high-dose niacin therapy suggest that this is not a helpful combination for most people and there are safety concerns. The same issues are likely to arise with the combination of red yeast rice and high-dose niacin therapy, so this combination should be carefully evaluated. For more details about the effects of statins given with high-dose niacin, see the Niacin section of the B Vitamins Product Review (which includes our tests of niacin and other B vitamins).

Be aware that some evidence suggests that taking phytosterols in addition to red yeast rice may be helpful.

For more information about red yeast rice (including's product tests), see the Red Yeast Rice Supplements Review >>

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January 14, 2018

I once took a dose of Lo & Slow Niacin (I think about 750 mg) along with 600 mg of Red Yeast rice, about an hour after taking Viagra, and while on a course of the antibiotic Bactrim. The next day I lost my ability to speak, and could not identify a stethoscope hanging around my doctor's neck. I was rushed to the hospital and treated for a TIA (mini stroke). My liver enzymes soared from the 20's to the 500's. Though overt symptoms disappeared within 30 minutes of their onset, and scans revealed no brain damage, my doctors declared me to be an afib patient, and put me on a blood thinner for the rest of my life - even though I suspect the event was evidence of hepatic encepalopathy (sp?). So - I would definitely not recommend mixing red yeast rice with high dose niacin - especially if you use ED drugs. Hope this is helpful.

January 10, 2018

My doctor has had me taking both Red Yeast Rice and SloNiacin for nearly a year and the resulting decreases in both cholesterol and triglycerides have been remarkable. The combination is producing a better result than I had from a popular prescription statin drug and the leg pains I was having with the statin no longer occur.

July 27, 2016

Consumer Reports says Red yeast rice is one of the fifteen worse supplements we can take. See the September 2016 issue on supplements.
July 28, 2016

Hi Linda - The reasons given by Consumer Reports for "avoiding" this supplement relate to the effects of the cholesterol-lowering statin compounds it naturally contains. The warnings are similar to those for statin drugs. CR also notes that red yeast rice can, not surprisingly, increase the effects and side-effects of statin drugs.

Red yeast rice has been shown to be very effective, with minimal side effects, in well-performed, independent clinical studies, so we do not agree that it is supplement to avoid. However, it is certainly one that must be carefully selected (due wide variations in lovastatin content and the potential for contamination) and properly used, as discussed in detail in our Red Yeast Rice Supplements Review.

June 23, 2021


First, CR is not a medical entity. They are basing their 'observation' on one simple fact: red yeast rice contains a molecule that is identical to what is found in a powerful prescription drug. CR assumes most people who take 'supplements', do not consult with their doctors, assume 'more is better' and do not consider side-effects (again, assuming because it is on the shelf at Wal-Mart, someone made sure it was safe!). Do those things, and yes, it can be dangerous.

Red yeast rice can safely be used as a supplement if you do the following (reverse of those CR observations); Tell your doctor. Do not take more than recommended. Assume everything can cause side-effects until you, or your doctor tells you otherwise. Many doctors are completely OK with patients who prefer a natural alternative to prescription drugs, especially when costs are concerned.

Red yeast rice is also eaten by millions of people in the world, and has been for thousands of years.

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