Titanium dioxide is an FDA approved food coloring agent commonly added to pills to make them white. Although only very small amounts are used in supplements (less than 1% of the formulation) animal studies have raised concerns that it could be carcinogenic and adversely affect the immune system and digestive tract. (Be aware that the European Food Safety Agency (EFSA) (the European equivalent of the FDA) concluded that titanium dioxide is not considered safe for use as a food additive.)
See our Review article about Inactive Ingredients/Excipients in Supplements for more information about the safety of titanium dioxide and other common ingredients used to enhance or stabilize dietary supplement formulations, including preservatives, coloring and coating agents, and binders and fillers.
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