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Eliquis Supplement Interactions -- box of Eliquis


Yes, several popular herbal supplements can impact the effectiveness of apixaban (Eliquis), rivaroxaban (Xarelto), betrixaban (Bevyxxa), and other anticoagulant drugs (blood-thinners) classified as direct factor Xa inhibitors. These blood-thinners are broken down in the body by the liver enzyme CYP3A4. Some supplements can activate this enzyme, which can reduce the amount of these medications in the body, while other supplements can inhibit this enzyme, which can lead to excessive blood levels of these medications. Also, be aware that some supplements interact with the anticoagulant dabigatran (Pradaxa), a direct thrombin inhibitor.

For details about which supplements can interfere with these anticoagulants, read the full answer.

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