Our Members Asked:
Are there supplements I should avoid when taking apixaban (Eliquis) or similar blood thinner drugs like Xarelto?
Yes, several popular herbal supplements can impact the effectiveness of apixaban (Eliquis), rivaroxaban (Xarelto), betrixaban (Bevyxxa), and other anticoagulant drugs (blood-thinners) classified as direct factor Xa inhibitors.
These blood-thinners are broken down in the body by the liver enzyme CYP3A4. Supplements that activate this enzyme may reduce the amount of these medications in the body, while supplements inhibit this enzyme may lead to excessive blood levels of these medications.
Other supplements have their own blood-thinning or clot-promoting effects, which, correspondingly, may increase or reduce the effectiveness of these blood thinners.
Also, be aware that some supplements interact with the anticoagulant dabigatran (Pradaxa), a direct thrombin inhibitor.
For details about which supplements can interfere with these anticoagulants, read the full answer.