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Answer:

Grapefruit seed extract (GSE or GFSE) supplements are promoted for a wide range of uses, from treating fungal infections and bacterial infections (such as urinary tract infections) to lowering blood sugar and cholesterol, and alleviating gastrointestinal symptoms. However, the evidence supporting many for these uses is limited. There are also potential drug interactions of which you need to be mindful. See the full answer >>

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10 Comments

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lisa21540
December 7, 2020

Hi consumer labs, I would very much like to see an immediate study on grapefruit seed extract also please and thank you

ConsumerLab.com
December 7, 2020

As noted below, as the evidence remains weak for grapefruit seed extract and our reader surveys continue to show little interest in it relative to other supplements, we are not currently planning on testing this category. If things change, we will reassess.

Christy19540
April 19, 2020

Hi ConsumerLab: Since moving to Florida & lots of air-conditioning, I’ve had problems with nasal congestion. My sister, a long-time Florida resident, recommended Nutribiotic Nasal Spray (the one without the herbs). It has completely solved the problem. I use it once or twice a day. I would also be happy to see a report on GSE, grapefruit seed extract. Thanks!

Candice11278
September 14, 2016

I can't find anywhere (including in the links provided) that you name the company or companies that sell the adulterated GSE. I regularly use GSE in a cleaning solution. I need to know the name of the offending company(ies).

ConsumerLab.com
September 14, 2016

Hi Candice - Unfortunately the brand names and manufacturers of the grapefruit seed extracts were not published.

Melanie11277
September 14, 2016

Do you have plans to do a test review of GSE? I take a 125mg table daily because I tend to have a yeast problem. I also take more if I feel a bladder infection coming on. I also put drops of GSE in my dogs water which has greatly improved their breath and a drop on my toothbrush. I also use the drops along with drops of lemon oil to clean my kitchen counter tops so I am a big fan of this supplement. The brand I take is NutriBiotic and it does not list any of the additives you mention. I hope you review this product soon.
Thanks, Melanie

ConsumerLab.com
September 17, 2016

Hi Melanie - Thanks for sharing your experience. Based on the 2015 ConsumerLab.com Survey of our readers, only a small number of people indicated using grapefruit seed extract, so we do not currently have plans to test such products - but we will continue to reassess this each year.

Tracey11276
September 14, 2016

I'm not sure what you use for sources for finding research but I have several papers that refer to the benefits of Grapefruit seed extract on borrelia (Lyme). Here's one, http://link.springer.com/article/10.1007%2Fs15010-007-6105-0?LI=true

ConsumerLab.com
September 14, 2016

Hi Tracy - The study you cite is not a clinical study (i.e., in people, which would be called an "in vivo" study) but a laboratory experiment ("in vitro"). We cite numerous laboratory experiments - but clinical studies are necessary to determine efficacy and side effects.

pfin99
June 16, 2021

pfin99
Yes, but I have a chronically furious grand daughter with no mood modulation, at all. Her parents are not eager for medication and she refuses. There will never be an in vivo study of grapefruit juice (due to commercial realities). We have to go on observations. Has grapefruit juice been helpful for anyone with suspected or diagnosed Lyme disease?

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