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Question:
Can fisetin, also called Cognisetin and Novusetin, really improve memory?

Answer:
Fisetin is a flavonol with antioxidant properties that is promoted for improving brain health, cognition and memory -- although the evidence for this use rests only on animal studies. Laboratory research also suggests anti-cancer activity, and that it may lessen complications of type 1 diabetes. It has been sold as the branded ingredient Cognisetin, by Cyvex Nutrition, and is now sold by the same company as Novusetin.

Fisetin is found in plants such as the Japanese fruit wax tree (Rhus succedanea), and, in very small amounts, in strawberries, tomatoes, onions and other foods. However, you would have to eat about 1 pound of strawberries a day to get the dose typically provided in fisetin supplements (Maher, PLoSONE 2011). 

Fisetin has been studied by researchers at the Salk Institute for Biological Studies, which own a patent for fisetin as a memory enhancer (U.S. Patent 7897637 B2). Laboratory and animal studies have found that it protects and promotes the growth of brain cells, and enhances memory in mice (Maher, Proc Natl Acad Sci 2006). However, there are no published studies on the effect of fisetin on memory, or its long-term safety at the dose provided by supplements, in people.  

Based on amounts used in animal studies, a dose between 50 and 150 mg day has been proposed as potentially beneficial in people. Most supplements provide between 50 and 100 mg per daily serving and cost between $11 and $15 for a 30 day supply, although combination supplements that contain additional ingredients can cost as much as $45.

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JARKKO16347   January 11, 2018
"However, you would have to eat about 10 pounds of strawberries a day to get the dose typically provided in fisetin supplements".

Really? Why do I see this claim at several websites? I believe this is wrong.

1 pounds = about 450g. I believe you get about 70mg of Fisetin from 450g of strawberries.

ConsumerLab.com   January 11, 2018
You are right. About 1 pound of strawberries would provide about 73 mg of fisetin. This has been corrected above. Thank you!

Ulana1708   May 10, 2015
As a botanist, it always startles me to read botanical names that are written incorrectly. The botanical name of a plant is always two part, the genus and then the species. The first (or the genus) is always capped but the second NEVER is. It is ALWAYS lower case. So the reference above should read as Rhus succedanea.
This may seem like a moot point to many but as this is a very technical site, I thought I should mention it. I have seen quite a few supplements being sold on the shelf labeled incorrectly in this manner and it does make me question the knowledge of the manufacturer. Would you want to buy medication that was misspelled?
As a member, I respect what Consumerlabs does and I want it to have the highest standards.

ConsumerLab.com   May 11, 2015
Hi Ulana - Thank you for letting us know about the mistake. This has been corrected.

This CL Answer initially posted on 5/9/2015. Last updated 1/11/2018.

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