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Question:
Can glycine really help improve my sleep?

Answer:
Glycine is a non-essential amino acid (meaning that it can be made in the body and is not required from the diet) which acts as a neurotransmitter. Although glycine supplements are sometimes promoted as having a calming effect or improving sleep, the studies supporting these claims have been small, short-term, and involved a company which sells glycine. For more details, see the full answer >>

For more information, see the Encyclopedia article about Glycine.

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For information about other supplements which may help to improve sleep, see the CL Answers to the questions below.



Can L-theanine help as a sleep aid? Will ConsumerLab.com be testing these supplements? >>

What is the best way to take melatonin to get a good night's sleep? >>

Which supplements can help me sleep? >>

Is it safe to take melatonin when taking prescription sedatives or sleep aids like lorazepam (Ativan) or zolpidem (Ambien)? >>



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JARKKO16679   April 5, 2018
Perhaps ConsumerLab could fund a research to verify sleep results, and publish abstract at PubMed, with full study readable only for paying ConsumerLab members?

Main problem with previous sleep studies:
* Very short time (7 days or less), so there is no information is there tolerance or should Glycine be cycled (on, off, so not taking 3g every night).
* Only 3g dose tested. Why not compare for example 3g, 6g and 9g.
* Industry funded studies.
* What was the placebo? Glycine is a sweet amino acid. In industry funded studies, perhaps the employees were able to taste glycine vs. placebo.
Quite soluble to water, solubility is 25g of glycine to 100mL water, at 25 Celcius temperature.
* Seems to work for both men and women, but was it tested with different age groups of adults, for example 20y, 40y, 60y, 80y?

Glycine is VERY cheap, so at least that is not a problem. Carlson Labs, Glycine, Amino Acid Powder, 3.53 oz (100 g), costs about $5 for consumers per 100g. That would mean about $5 per month per person, if taken 3g/day.

ConsumerLab.com   April 5, 2018
Hi Jarkko - Thank you for your comment and suggestion; ConsumerLab does a lot of laboratory testing of products, but we don't conduct clinical studies.

This CL Answer initially posted on 9/27/2016. Last updated 7/26/2017.

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