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White Plains, New York, October 13, 2011 — Dietary supplements with SAMe (S-adenosyl-methionine) are used to treat osteoarthritis as well as depression, but only 7 out of ten SAM-e supplements recently selected for testing by met all quality criteria. No SAM-e was found in one supplement and another provided only 75% of its listed amount of the ingredient. The enteric coating on a SAM-e product for dogs and cats did not last long enough to properly protect the contents of the pill. Nearly all SAMe supplements are enteric coated to protect the SAM-e from degradation and prevent stomach upset.

In 2010, $122 million of SAM-e supplements were sold in the U.S. according to Nutrition Business Journal. SAM-e is among the more expensive supplements and prices range widely. The best price among products that passed testing was 53 cents for a 400 mg dose, while a similar dose cost over $2.50 from two products and over $3.00 from the product that contained only 75% of its claimed amount.'s Product Review of SAMe Supplements is available at The report provides clinical information about SAMe, how it is used, and test results and comparisons for the ten products selected by and 4 products that passed the same testing through its Voluntary Certification Program. It also includes information about one product similar to one that passed testing. Brands covered in the report are CVS, Doctor's Best, Integrative Therapeutics Vitaline, Jarrow Formulas, Life Extension, Maxam Nutraceutics, Natrol, Nature Made, Nature's Bounty, Nature's Sunshine, NSI (Vitacost), Sogeval Laboratories, Source Naturals, Vitamin Depot, and Vitamin Shoppe. is a leading provider of consumer information and independent evaluations of products that affect health and nutrition. The company is privately held and based in Westchester, New York. It has no ownership from, or interest in, companies that manufacture, distribute, or sell consumer products.

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