Drug Tests
Wellbutrin vs. Generic Bupropion Review

Reviewed and edited by Tod Cooperman, M.D. Tod Cooperman, M.D.
 Initial Posting: 10/12/07  Last Updated 10/17/13      

Generic Bupropion Is Not Always The Same As Name-Brand Wellbutrin

CL Tests Reveal Differences Between Generic Bupropion and Name-Brand Wellbutrin   

Make sure the medicine you take is equivalent to the brand name drug! Isn't your health worth it?
Many people believe that generics are equivalent to brand name drugs. And the FDA says they are "bioequivalent." But many consumers have reported serious problems when switched from the anti-depressant Wellbutrin to a generic form of this drug. ConsumerLab.com tested and compared several bupropion products. What we found will shock you.

A once-a-day (XL) generic bupropion XL released its ingredient at a very different rate than Wellbutrin XL. Differences in how products dissolve may explain the side-effects and return of depression reported by some patients switched to a generic. And two twice-a-day (SR) generics also differed from one another.

If you or a loved one uses generic Wellbutrin, you need to know how products may differ.

In this Review, you'll get ConsumerLab's test results for these products and much more! You must subscribe to get the full review in which you'll discover:
    • Which products behaved like the original Wellbutrin in our tests and which did not.
    • What these differences can mean to you.
    • A list of generic bupropion products by distributor and manufacturer to help you tell them apart, including versions from Par (previously Anchen) and Sandoz.  
    • Other time-released generics that may differ from the original drugs.
    • Strategies and tips to get the right drug.

If you already are a member, SIGN IN now.
In a major reversal, the FDA declared that two generic versions of bupropion hydrochloride XL 300 are not bioequivalent to Wellbutrin XL 300 mg.  These products were on the market for many years. For details, see the Update at the top of the full report.
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