- What is lysine? Lysine (L-lysine) is an essential amino acid found in many protein-rich foods (see Lysine in Food) and is needed for proper growth and other critical functions (see details in What It Is).
- What are the health benefits of lysine? As a supplement, lysine may help prevent cold sores (herpes simplex labialis), genital herpes lesions, and canker sores. Although it is also found in topical products for cold sores, it is not known to be active topically (See details in What It Does).
- How much lysine to take? Typical daily dosage is 1,000 to 3,000 mg (see details in Quality Concerns).
- Lysine has also been used to prevent/treat feline herpesvirus 1 infection — but there is no clinical evidence to support this use and it is not recommended (see details in What It Does, For Cats).
- What did CL's tests of lysine find? CL's tests found that all but one product contained their listed amounts of lysine (see details in What CL Found).
- Best value for lysine: The cost to obtain lysine from CL Approved products ranged from 4 cents to 33 cents per 1,000 mg (and up to 72 cents for cat products). See which CL Approved products provide the best value.
- To compare product test ratings, ingredients, and prices, see the Results Table.
- Lysine safety and side effects: People with kidney disease, gallstones, elevated cholesterol, and glutaric acidemia type I should exercise caution with lysine supplements (see details in Concerns and Cautions).
Lysine Supplements Review
Choose the Best Lysine Supplement. CL Tests Reveal Which Lysine Supplements Provide the Best Quality and Value

Lysine supplement brands compared in this review

21st Century L-Lysine for Cats

Andrew Lessman ProCaps Lysine

Carlson L-Lysine

CVS/pharmacy L-Lysine

Douglas Laboratories L-Lysine

Finest Nutrition [Walgreens] L-Lysine

GNC L-Lysine

Nature Made L-Lysine

Pet Naturals of Vermont L-Lysine for Cats

Puritan's Pride L-Lysine

Rexall L-Lysine

Rite Aid Pharmacy L-Lysine

Solaray L-Lysine

Solgar L-Lysine

Source Naturals L-Lysine

Spring Valley [Walmart] L-Lysine

Swanson Free-Form L-Lysine

Up & Up [Target] L-Lysine

Vitacost L-Lysine
Vitamin World L-Lysine
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Summary
- Which lysine supplements passed or failed testing
- How lysine supplements compare on quality and cost and which provide the best value.
- What lysine can and cannot do for your health, and your cat's health.
- How to read the labels, so you know how much lysine you can really expect from a product without being fooled.
- Lysine dosage for uses including cold sores, genital herpes lesions and canker sores.
- Concerns, drug interactions, and potential side-effects of lysine.
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